A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans

The Journal of Clinical Endocrinology and Metabolism
Elizabeth A McAninchAntonio C Bianco

Abstract

A common single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. To determine whether Thr92AlaD2 is associated with incident Alzheimer disease (AD). Population-based study; human brain tissue microarray. Community-based cohorts from Chicago and northeastern Illinois and religious clergymen from across the United States constituted the primary population. A representative sample of the U.S. population was used for secondary analyses. 3054 African Americans (AAs) and 9304 European Americans (EAs). Incident AD. In the primary population, AAs with Thr92AlaD2 had 1.3 times [95% confidence interval (CI), 1.02 to 1.68; P = 0.048] greater odds of developing AD. AAs from a second population with Thr92AlaD2 showed a trend toward increased odds of dementia (odds ratio, 1.33; 95% CI, 0.99 to 1.78; P = 0.06) and 1.35 times greater odds of developing cognitive impairment not demented (CIND; 95% CI, 1.09 to 1.67; P = 0.006). Meta-analysis showed that AAs with Thr92AlaD2 had 1.3 times increased odds of developing AD/dementia (95% CI, 1.07 to 1.58; P = 0.008). In EAs, no association was found between Thr92AlaD2 and AD, dementia, ...Continue Reading

References

Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Robin P PeetersTheo J Visser
Dec 4, 2003·Journal of Alzheimer's Disease : JAD·Julia L BieniasDenis A Evans
Aug 17, 2005·Neuroepidemiology·Kenneth M LangaRobert J Willis
Dec 17, 2005·Thyroid : Official Journal of the American Thyroid Association·Daniela MentucciaFrancesco S Celi
Nov 2, 2006·The Journal of Clinical Endocrinology and Metabolism·Niels GrarupOluf Pedersen
Nov 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Frank Jan de JongMonique M B Breteler
Sep 28, 2007·Nature Genetics·Matthew D MailmanStephen T Sherry
Sep 26, 2008·Endocrine Reviews·Balázs GerebenAntonio C Bianco
Nov 1, 2008·Bioinformatics·Andrew D JohnsonPaul I W de Bakker
Jan 29, 2010·The New England Journal of Medicine·Henry W Querfurth, Frank M LaFerla
Jun 23, 2010·European Journal of Endocrinology·José Miguel DoraAna Luiza Maia
Jan 25, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Robert S WilsonDavid A Bennett
Jul 16, 2011·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Eileen M CrimminsDavid R Weir
Dec 7, 2011·Thyroid : Official Journal of the American Thyroid Association·Saraswathy NairLeslie J Baier
Apr 5, 2012·Current Alzheimer Research·David A BennettRobert S Wilson
Apr 5, 2012·Current Alzheimer Research·David A BennettRobert S Wilson
Oct 30, 2012·Genomics & Informatics·Eun Pyo Hong, Ji Wan Park
Apr 11, 2013·JAMA : the Journal of the American Medical Association·Christiane ReitzUNKNOWN Alzheimer Disease Genetics Consortium
Jul 10, 2013·JAMA Neurology·Joshua M ShulmanDavid A Bennett
Mar 29, 2014·International Journal of Epidemiology·Amanda SonnegaDavid R Weir
Dec 30, 2014·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gunjan Joshi, Yanzhuang Wang
Jan 9, 2015·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A McAninchAntonio C Bianco
Jul 21, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Peter N TaylorColin M Dayan
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Kyle SteenlandWhitney Wharton
Feb 12, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Gyungah R JunLindsay A Farrer
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Maria Grazia CastagnaDomenico Salvatore
May 10, 2017·The Journal of Clinical Endocrinology and Metabolism·Marco MediciRobin P Peeters

❮ Previous
Next ❯

Citations

Aug 1, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Antonio C Bianco, Brian S Kim
Oct 24, 2018·The Journal of Clinical Investigation·Sungro JoAntonio C Bianco
Apr 30, 2019·Endocrine Reviews·Antonio C BiancoBarbara M L C Bocco
Jun 5, 2019·Nature Reviews. Endocrinology·Cristina LuongoDomenico Salvatore
Jul 10, 2019·Alcoholism, Clinical and Experimental Research·Arturo Hernandez
Aug 15, 2019·Thyroid : Official Journal of the American Thyroid Association·Mitsuru ItoAkira Miyauchi
Dec 12, 2019·Thyroid : Official Journal of the American Thyroid Association·Sheue-Yann Cheng
Mar 19, 2020·Thyroid : Official Journal of the American Thyroid Association·Sebastian NockJens Mittag
Apr 8, 2020·Thyroid : Official Journal of the American Thyroid Association·Fereidoun Azizi
Jul 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Matthew D Ettleson, Antonio C Bianco
Dec 11, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Jan Christoph UterThomas F Münte
Jul 30, 2019·Frontiers in Endocrinology·Elizabeth A McAninch, Antonio C Bianco
Oct 17, 2019·Endocrine·Wilmar M Wiersinga
Sep 29, 2020·Frontiers in Neuroscience·Pieter VancampSylvie Remaud
Feb 2, 2020·Nature Reviews. Endocrinology·Antonio C Bianco, Peter Taylor
Dec 7, 2018·The Journal of Clinical Investigation·Arturo Hernandez
Jan 16, 2021·Journal of Endocrinological Investigation·A A E MarcondesM O Ribeiro
Jun 6, 2020·Thyroid : Official Journal of the American Thyroid Association·Nerea LacámaraJose Carlos Moreno
Sep 28, 2020·Seminars in Cell & Developmental Biology·Gisele GiannoccoJanaina Sena de Souza
May 9, 2021·Endocrinology·Arturo HernandezDouglas Forrest
Oct 14, 2021·Thyroid : Official Journal of the American Thyroid Association·Alexandra M DumitrescuAntonio C Bianco

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.