Abstract
Global miRNA expression profile has been widely used to characterize human cancers. It is well established that genetic variants in miRNAs can modulate miRNA biogenesis and disease risk. Genome-wide miRNA microarray was employed for assessment of miRNA expression profile of gastric adenocarcinoma (GAC). The variants of significantly dysregulated miRNA were genotyped in test (715 cases and 804 controls) and validation (940 cases and 1050 controls) subject sets. MiRNA microarray revealed that 12 miRNAs including miR-107 significantly dysregulated in GAC tissues. The sequencing of the promoter of miR-107 identified 3 SNPs (rs11185777, rs78591545, and rs2296616) with minor allele frequency (MAF)>5%. Analyzing their association with GAC risk and prognosis revealed that the C allele of rs2296616 (T>C) was significantly associated with the decreased risk of GAC among the test, validation and combined sets (TC/CC vs. TT, adjusted OR=0.39, 95% CI=0.31-0.49 for the combined set). However, the C allele was related to an unfavorable prognosis of Cardia GAC (CGAC) (adjusted HR=1.49, 95% CI=1.01-2.20). In vivo evidence showed that the individuals with the rs2296616C allele had lower miR-107 expression compared with the homozygous T allele ca...Continue Reading
References
Apr 20, 2001·Proceedings of the National Academy of Sciences of the United States of America·V G TusherG Chu
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thian-Sze WongWilliam Ignace Wei
Jun 4, 2008·The Journal of Clinical Investigation·Zhibin HuHongbing Shen
Dec 19, 2008·Gut·K R FareedS Madhusudan
Jul 21, 2009·RNA·Guihua SunJohn J Rossi
Jul 25, 2009·Lancet·Henk H HartgrinkCornelis J H van de Velde
Jan 16, 2010·RNA·Alex Mas MonteysBeverly L Davidson
May 25, 2010·BMC Genomics·Limei QinDelin Mo
Jul 7, 2010·Cell·Graziano MartelloStefano Piccolo
Aug 31, 2010·Oncogene·W K K WuJ J Y Sung
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Oct 5, 2010·American Journal of Respiratory and Critical Care Medicine·Zhibin HuHongbing Shen
Oct 30, 2010·Journal of Cellular and Molecular Medicine·Xiaohua LiDaiming Fan
Nov 11, 2010·International Journal of Cancer. Journal International Du Cancer·Meilin WangZhengdong Zhang
May 27, 2011·Gut·M Constanza CamargoCharles S Rabkin
Dec 14, 2011·Oncogene·J DattaQ Pan
Feb 9, 2012·Nature Reviews. Genetics·Stephen J Chapman, Adrian V S Hill
Mar 14, 2012·Nature Reviews. Genetics·Amy E Pasquinelli
May 15, 2012·Gastroenterology·Jee Hoon Song, Stephen J Meltzer
Aug 1, 2012·Cancer Research·Meilin WangZhengdong Zhang
Dec 12, 2012·Neuroscience Letters·Lei ChenXiao-Dan Jiang
Apr 18, 2014·International Journal of Cancer. Journal International Du Cancer·Shu-Pin HuangBo-Ying Bao
Citations
Apr 19, 2016·Disease Markers·Zhifang JiaJing Jiang
Oct 9, 2016·Gene·Shizhi WangHua Jin
Jul 23, 2016·Scientific Reports·Fang YuanLin Zhang
Mar 25, 2016·PloS One·Xiaonan QiuZhengdong Zhang
Mar 21, 2018·BMC Complementary and Alternative Medicine·Xiaoni LiuXiaoxin Zhu
Nov 6, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jovana StojanovicStefania Boccia
Jul 13, 2019·Cancer Medicine·Li WangHuiyu Yang
Jan 19, 2018·Oncology Letters·Wenshuai LiJie Liu
Nov 1, 2017·Oncology Letters·Li LiangDaping Yang
Jan 9, 2019·Frontiers in Oncology·Han-Xi DingQian Xu
Aug 27, 2019·Cancer Medicine·Esmat AbdiFarhad Pourfarzi
Apr 16, 2016·International Journal of Oncology·David SmidMartin Pesta
Apr 25, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Weizhi WangZekuan Xu