A common mechanism for the interaction of nitric oxide with the oxidized binuclear centre and oxygen intermediates of cytochrome c oxidase.

The Journal of Biological Chemistry
Jaume TorresM T Wilson

Abstract

The reactions of nitric oxide (NO) with fully oxidized cytochrome c oxidase (O) and the intermediates P and F have been investigated by optical spectroscopy, using both static and kinetic methods. The reaction of NO with O leads to a rapid (approximately 100 s-1) electron ejection from the binuclear center to cytochrome a and CuA. The reaction with the intermediates P and F leads to the depletion of these species in slower reactions, yielding the fully oxidized enzyme. The fastest optical change, however, takes place within the dead time of the stopped-flow apparatus (approximately 1 ms), and corresponds to the formation of the F intermediate (580 nm) upon reaction of NO with a species that we postulate is at the peroxide oxidation level. This species can be formulated as either Fe5+ = O CuB2+ or Fe4+ = O CuB3+, and it is spectrally distinct from the P intermediate (607 nm). All of these reactions have been rationalized through a mechanism in which NO reacts with CuB2+, generating the nitrosonium species CuB1+ NO+, which upon hydration yields nitrous acid and CuB1+. This is followed by redox equilibration of CuB with Fea/CuA or Fea3 (in which Fea and Fea3 are the iron centers of cytochromes a and a3, respectively). In agreement...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T H StevensS I Chan
Mar 26, 1992·Nature·G T Babcock, M Wikström
Aug 23, 1991·Biochimica Et Biophysica Acta·A J MoodyP R Rich
Nov 11, 1980·Biochemistry·G W BrudvigS I Chan
Feb 12, 1981·Biochimica Et Biophysica Acta·P Nicholls, G A Chanady
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·M Wikström
May 1, 1982·The Biochemical Journal·M T WilsonT Vänngård
Jan 15, 1995·European Journal of Biochemistry·T Soulimane, G Buse
Oct 28, 1994·Biochemical and Biophysical Research Communications·X J ZhaoW S Caughey
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C VarotsisG T Babcock
Mar 21, 1996·Nature·M I VerkhovskyM Wikström
Jun 13, 1996·Biochimica Et Biophysica Acta·G L Liao, G Palmer
Jan 1, 1996·Methods in Enzymology·J Torres, M T Wilson
Aug 1, 1996·Biochemical Society Transactions·J TorresM T Wilson
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·M I VerkhovskyM Wikström
Dec 27, 1996·The Journal of Biological Chemistry·A GiuffrèM Brunori
Feb 1, 1996·Methods : a Companion to Methods in Enzymology·A M Killary, S T Lott
Aug 1, 1997·Biochemical Society Transactions·M T WilsonM A Sharpe
Aug 1, 1997·Biochemical Society Transactions·J Torres, M T Wilson
Nov 7, 1996·Chemical Reviews·Shelagh Ferguson-Miller, Gerald T. Babcock
Nov 7, 1996·Chemical Reviews·Bruce A. Averill

❮ Previous
Next ❯

Citations

Jun 21, 2005·Archives of Biochemistry and Biophysics·Yeong-Renn ChenJay L Zweier
Sep 5, 2002·Biochemical and Biophysical Research Communications·Clive ButlerPaolo Sarti
May 24, 2003·Biochemical and Biophysical Research Communications·Silvia AlvarezAlberto Boveris
Nov 26, 2002·Free Radical Biology & Medicine·Guy C Brown, Vilmante Borutaite
Mar 5, 2003·Free Radical Biology & Medicine·Paolo SartiMaurizio Brunori
Feb 14, 2002·Trends in Biochemical Sciences·Chris E Cooper
Aug 8, 2012·Inorganic Chemistry·Marie M MelzerTimothy H Warren
Mar 28, 2012·Chemical Research in Toxicology·Jose Carlos Toledo, Ohara Augusto
Aug 2, 2007·Antioxidants & Redox Signaling·Fernando AntunesEnrique Cadenas
Jan 23, 1999·Current Opinion in Nephrology and Hypertension·M S WolinT H Hintze
Feb 20, 2008·Biochemistry. Biokhimii︠a︡·A N OsipovYu A Vladimirov
Nov 29, 2002·Molecular Pathology : MP·K Stuart-Smith
Jul 25, 2000·Biochemical and Biophysical Research Communications·P SartiM Brunori
Nov 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fernando AntunesEnrique Cadenas
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Miriam Palacios-CallenderSalvador Moncada
Jan 8, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Brandon J ErdleAlice P Pentland
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Maria G MasonChristopher E Cooper
Jun 22, 2012·International Journal of Cell Biology·Ricardo M SantosJoão Laranjinha
Nov 30, 2006·Redox Report : Communications in Free Radical Research·Tiffany A Reiter
Feb 7, 2015·Free Radical Biology & Medicine·Robert van LithGuillermo A Ameer
Dec 27, 2005·Progress in Neurobiology·Julie Y H ChanSamuel H H Chan
May 28, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Somnath GhoshBiplab Mondal
Jun 28, 2000·FEBS Letters·J TorresM T Wilson
Apr 26, 2005·FEBS Letters·Alessandro GiuffrèPaolo Sarti
Mar 2, 2005·Lasers in Surgery and Medicine·Tiina I KaruNatalia I Afanasyeva
Jan 24, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Moushumi Sarma, Biplab Mondal
Dec 6, 2011·Chemistry : a European Journal·Wai-Lun ManTai-Chu Lau
Nov 26, 1998·The Journal of Biological Chemistry·A GiuffrèM T Wilson
Apr 17, 2020·Antioxidants & Redox Signaling·Marianela RodríguezRafael Radi
Dec 22, 2009·Angewandte Chemie·Marie M MelzerTimothy H Warren
Mar 1, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Pankaj KumarBiplab Mondal
Jul 6, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Moushumi SarmaBiplab Mondal
Nov 17, 2004·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Stephen C Land

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.