A common molecular signature of intestinal-type gastric carcinoma indicates processes related to gastric carcinogenesis

Oncotarget
Renata BinatoEliana Abdelhay

Abstract

Gastric carcinoma (GC) is one of the most aggressive cancers and the second leading cause of cancer death in the world. According to the Lauren classification, this adenocarcinoma is divided into two subtypes, intestinal and diffuse, which differ in their clinical, epidemiological and molecular features. Several studies have attempted to delineate the molecular signature of gastric cancer to develop new and non-invasive screening tests that improve diagnosis and lead to new treatment strategies. However, a consensus signature has not yet been identified for each condition. Thus, this work aimed to analyze the gene expression profile of Brazilian intestinal-type GC tissues using microarrays and compare the results to those of non-tumor tissue samples. Moreover, we compared our intestinal-type gastric carcinoma profile with those obtained from populations worldwide to assess their similarity. The results identified a molecular signature for intestinal-type GC and revealed that 38 genes differentially expressed in Brazilian intestinal-type gastric carcinoma samples can successfully distinguish gastric tumors from non-tumor tissue in the global population. These differentially expressed genes participate in biological processes imp...Continue Reading

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Citations

Jul 15, 2020·BMC Gastroenterology·Paulo Pimentel AssumpçãoMoyses Szklo
Feb 6, 2020·Anti-cancer Agents in Medicinal Chemistry·Amir H AalamiAmirhossein Sahebkar
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Aug 10, 2021·Cancer Biomarkers : Section a of Disease Markers·Everton Cruz SantosEliana Saul Furquim Werneck Abdelhay

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Datasets Mentioned

BETA
GSE15456
GSE15459
GSE19826
GSE22377
GSE29272
GSE37023
GSE47007
GSE57308

Methods Mentioned

BETA
surgical resection
chip
RNA-seq
Assay
PCR

Software Mentioned

Affymetrix Expression Console
GeneGO
GraphPad
survminer R
Partek
[UNK]
sva Bioconductor R package
Gene 6000 Series
Genomic Data Commons
CGAbiolinks Bioconductor R

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