A common mutation of the MYH gene is associated with increased DNA oxidation and age-related diseases

Free Radical Biology & Medicine
Caixia SunYaping Wang

Abstract

We describe a common mutation of the MYH gene, which is involved in the repair of oxidative damage to DNA, and its relationship to age, levels of 8-OHdG, and circulating levels of interleukin-1. We studied 1146 "healthy" and 562 unselected Chinese subjects. We observed a reverse insertion of the AluYb8 sequence (AluYb8MYH) to be homozygous in approximately 25.8% of the healthy Chinese population age 20-29 years, with the incidence of homozygosity decreasing to 15.7% by age 50-59 years. Because subjects were selected on the basis of absence of disease during medical screening, this suggests that homozygosity for this gene has a marked impact on the development of age-related or chronic diseases or mortality. Because the MYH gene is involved in DNA repair we assessed whether homozygous carriage of this gene was associated with increased levels of 8-OHdG in the leukocytic DNA of carriers. The level of 8-OHdG increased from 3.8 8-OHdG/10(6) dG in wild-type carriers to 10.8 8-OHdG/10(6) dG in homozygous carriers, suggesting that the presence of the mutation was associated with impaired DNA repair. Because this mutation might be associated with the increased development of age-related or chronic disease and inflammation, we also meas...Continue Reading

Citations

Jun 22, 2012·Oxidative Medicine and Cellular Longevity·Zhenming CaiYaping Wang
Mar 20, 2013·Mutation Research·Filomena MazzeiMargherita Bignami
Jul 12, 2012·Biochemical and Biophysical Research Communications·Zhenming CaiYaping Wang
Feb 28, 2015·Environmental Science & Technology·Xinxiu LiYaping Wang
Jun 22, 2010·Molecular and Cellular Endocrinology·Caixia SunYaping Wang
Mar 22, 2015·Mutation Research. Reviews in Mutation Research·Fabrícia Lima FontesLucymara Fassarella Agnez-Lima
Aug 25, 2016·Frontiers in Genetics·Rania Nakad, Björn Schumacher
Jun 14, 2017·Journal of Ovarian Research·Fei DengXiaoxiang Chen
Aug 22, 2020·World Journal of Clinical Oncology·Maria Cristina CuriaGitana Maria Aceto

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