A common neural circuit mechanism for internally guided and externally reinforced forms of motor learning.

Nature Neuroscience
Erin HiseyRichard Mooney

Abstract

The complex skills underlying verbal and musical expression can be learned without external punishment or reward, indicating their learning is internally guided. The neural mechanisms that mediate internally guided learning are poorly understood, but a circuit comprising dopamine-releasing neurons in the midbrain ventral tegmental area (VTA) and their targets in the basal ganglia are important to externally reinforced learning. Juvenile zebra finches copy a tutor song in a process that is internally guided and, in adulthood, can learn to modify the fundamental frequency (pitch) of a target syllable in response to external reinforcement with white noise. Here we combined intersectional genetic ablation of VTA neurons, reversible blockade of dopamine receptors in the basal ganglia, and singing-triggered optogenetic stimulation of VTA terminals to establish that a common VTA-basal ganglia circuit enables internally guided song copying and externally reinforced syllable pitch learning.

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Citations

Jul 10, 2018·Annual Review of Neuroscience·David M Schneider, Richard Mooney
Jul 12, 2018·Journal of Neurophysiology·Pavel A PuzereyJesse H Goldberg
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Feb 23, 2020·Current Opinion in Neurobiology·Richard Mooney
Apr 7, 2021·Integrative and Comparative Biology·Matheus Macedo-Lima, Luke Remage-Healey
May 27, 2021·Integrative and Comparative Biology·Charlotte L BarkanErik Zornik
Jun 2, 2020·Current Opinion in Neurobiology·Richard BertramFrank Johnson

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