PMID: 7543360Nov 1, 1994Paper

A common RNA loop motif as a docking module and its function in the hammerhead ribozyme

Nature Structural Biology
B Wimberly

Abstract

Here I present a three-dimensional model of a novel element of RNA tertiary structure. A common loop motif composed of adjacent, sheared G.A and A.N non-canonical base pairs is proposed to form long-range tertiary interactions with other RNA residues. The widespread distribution of this G.A/A.N docking module suggests that the putative long-range docking interaction plays an important role in specifying the tertiary structure of large RNAs, and perhaps the quaternary structure of some intermolecular RNA-RNA interactions. Application of this docking module hypothesis to the hammerhead ribozyme provides crucial constraints for the calculation of three-dimensional models of its self-cleaving conformation.

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Citations

Dec 11, 2002·Journal of Molecular Biology·Jung C LeeRobin R Gutell
Jul 20, 2002·Current Opinion in Structural Biology·Robin R GutellJamie J Cannone
Oct 10, 1997·Nucleic Acids Research·R J CarterS R Holbrook
Nov 25, 2004·Journal of Molecular Biology·Jung C Lee, Robin R Gutell
Oct 3, 2003·Chembiochem : a European Journal of Chemical Biology·Boris FürtigHarald Schwalbe
Jul 25, 2000·The Journal of Biological Chemistry·B SargueilJ M Burke
Dec 1, 2018·Nature Communications·Erik W HartwickJeffrey S Kieft
Dec 15, 1995·The Journal of Biological Chemistry·S E ButcherJ M Burke
Jul 17, 2001·Journal of Molecular Biology·T ElgavishR R Gutell
Nov 25, 2000·Journal of Molecular Biology·R R GutellM J Serra
Oct 24, 1998·Journal of Molecular Biology·N B Leontis, E Westhof

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