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A common sequence motif associated with recombination hot spots and genome instability in humans

Nature Genetics

Jan 24, 2009

Simon MyersGil McVean

Abstract

In humans, most meiotic crossover events are clustered into short regions of the genome known as recombination hot spots. We have previously identified DNA motifs that are enriched in hot spots, particularly the 7-mer CCTCCCT. Here we use the increased hot-spot resolution afforded by th...read more

Mentioned in this Paper

Pyotraumatic Dermatitis
Abnormal Degeneration
Genomic Stability
Selfish DNA
Recombination, Genetic
Gene Deletion Abnormality
Minisatellite Repeats
Homologous Recombination
Mitochondria
Deletion Mutation
9
382
1
Paper Details
References
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  • Citations240
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  • References29
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A common sequence motif associated with recombination hot spots and genome instability in humans

Nature Genetics

Jan 24, 2009

Simon MyersGil McVean

PMID: 19165926

DOI: 10.1038/ng.213

Abstract

In humans, most meiotic crossover events are clustered into short regions of the genome known as recombination hot spots. We have previously identified DNA motifs that are enriched in hot spots, particularly the 7-mer CCTCCCT. Here we use the increased hot-spot resolution afforded by th...read more

Mentioned in this Paper

Pyotraumatic Dermatitis
Abnormal Degeneration
Genomic Stability
Selfish DNA
Recombination, Genetic
Gene Deletion Abnormality
Minisatellite Repeats
Homologous Recombination
Mitochondria
Deletion Mutation
9
382
1

Similar Papers Found In These Feeds

DNA Damage

Cells are subjected to several DNA damaging events on a daily basis which results in the induction of DNA damage signaling and repair cascades to ensure genomic stability. Here is the latest research pertaining to DNA damage.

Chromosomal Deletion

Chromosomal deletion includes the loss of a gene sequence of DNA. The location and the genes deleted determines the significance of this abnormality. There are many identified genetic disorders that are a result from chromosomal deletion including cri du chat and Prader-Willi syndrome. Discover the latest research on chromosomal deletions here.

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Science

PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice

ScienceJanuary 2, 2010
Frédéric BaudatBernard de Massy
Paper Details
References
  • References29
  • Citations240
123
  • References29
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