A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI.

The Journal of Biological Chemistry
Bruce D WinesP Mark Hogarth

Abstract

The transmembrane (TM) region of the Fc receptor-gamma (FcRgamma) chain is responsible for the association of this ubiquitous signal transduction subunit with many immunoreceptor ligand binding chains, making FcRgamma key to a number of leukocyte activities in immunity and disease. Some receptors contain a TM arginine residue that interacts with Asp-11 of the FcRgamma subunit, but otherwise the molecular basis for the FcRgamma subunit interactions is largely unknown. This study reports residues in the TM region of the FcRgamma subunit are important for association with the high affinity IgE receptor FcepsilonRI and a leukocyte receptor cluster member, the IgA receptor FcalphaRI. FcRgamma residue Leu-21 was essential for surface expression of FcepsilonRIalpha/gamma2 and Tyr-8, Leu-14, and Phe-15 contributed to expression. Likewise, detergent-stable FcRgamma association with FcalphaRI was also dependent on Leu-14 and Leu-21 and in addition required residues Tyr-17, Tyr-25, and Cys-26. Modeling the TM regions of the FcRgamma dimer indicated these residues interacting with both FcalphaRI and FcepsilonRI are near the interface between the two FcRgamma TM helices. Furthermore, the FcRgamma residues interacting with FcalphaRI form a l...Continue Reading

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Citations

Jul 30, 2011·The Journal of Biological Chemistry·Lawren C Wu
Apr 27, 2012·European Journal of Immunology·Marielle A OttenMarjolein van Egmond
Jun 22, 2011·MAbs·Jantine E Bakema, Marjolein van Egmond
Aug 23, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul A RamslandP Mark Hogarth
Oct 27, 2015·Immunological Reviews·Alicia M ChenowethP Mark Hogarth
Oct 27, 2015·Immunological Reviews·Esil AleydMarjolein van Egmond
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edwin LeeansyahAnthony Jaworowski

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