A Common Variant of NGEF Is Associated with Abdominal Visceral Fat in Korean Men

PloS One
Hyun-Jin KimBelong Cho

Abstract

Central adiposity, rather than body mass index (BMI), is a key pathophysiological feature of the development of obesity-related diseases. Although genetic studies by anthropometric measures such as waist circumference have been widely conducted, genetic studies for abdominal fat deposition measured by computed tomography (CT) have been rarely performed. A total of 1,243 participants who were recruited from two health check-up centers were included in this study. We selected four and three single-nucleotide polymorphisms (SNPs) in NGEF and RGS6, respectively, and analyzed the associations between the seven SNPs and central adiposity measured by CT using an additive, dominant, or recessive model. The participants were generally healthy middle-aged men (50.7 ± 5.3 years). In the additive model, the rs11678490 A allele of NGEF was significantly associated with total adipose tissue, visceral adipose tissue (VAT), and subcutaneous adipose tissue (all P < 0.05). The AA genotype of this SNP in the recessive model showed a more significant association with all adiposity traits, and its association with VAT remained significant even after adjustment for BMI (P = 0.005). In the overall or visceral obesity group analysis, the AA genotype o...Continue Reading

References

Apr 6, 1999·Radiology·T YoshizumiY Matsuzawa
Jul 11, 2001·Obesity Research·Y W ParkD Gallagher
Mar 6, 2004·Stroke; a Journal of Cerebral Circulation·Yun-Mi SongShah Ebrahim
Feb 1, 2006·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T KadowakiH Ueshima
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
Dec 17, 2008·Nature Genetics·Cristen J WillerUNKNOWN Genetic Investigation of ANthropometric Traits Consortium
Feb 27, 2009·Diabetes Care·Stacy A PorterCaroline S Fox
Oct 12, 2010·Nature Genetics·Elizabeth K SpeliotesRuth J F Loos
Sep 29, 2011·Circulation·Marc-Andre CornierUNKNOWN Council on the Kidney in Cardiovascular Disease, and Stroke Council
Jan 31, 2013·Annals of the New York Academy of Sciences·Qianghua Xia, Struan F A Grant
Jun 5, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Marzena ChrostowskaKrzysztof Narkiewicz
Jul 16, 2013·Journal of the American College of Cardiology·Kathryn A BrittonCaroline S Fox
Sep 28, 2013·Journal of Obesity·Giovanni De Pergola, Franco Silvestris

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Citations

Jan 17, 2017·Endocrine Journal·Hyun-Jin KimKyoung-Bok Min
Apr 26, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-J KimB Cho
Oct 28, 2019·Pharmacogenetics and Genomics·Henrik Thyge Corfitsen, Antonio Drago
Jul 26, 2016·Genomics & Informatics·Ye Seul BaeJong Il Kim
Mar 2, 2018·Oncotarget·Agata Lichawska-CieslarJolanta Jura
Sep 3, 2020·International Journal of Molecular Sciences·Sandro MicheliniMatteo Bertelli
Jan 30, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Su-Min JeongSeo Eun Hwang

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Methods Mentioned

BETA
Genotyping
Assay

Software Mentioned

SAS
NGEF
PLINK
Rapidia

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