A Common Variation in the Caveolin 1 Gene Is Associated with High Serum Triglycerides and Metabolic Syndrome in an Admixed Latin American Population

Metabolic Syndrome and Related Disorders
Gustavo Mora-GarcíaClaudio Jaime Gomez-Alegria

Abstract

The caveolin 1 (CAV1) gene has been associated with metabolic traits in animal models and human cohorts. Recently, a prevalent variant in CAV1 has been found to be related to metabolic syndrome in Hispanics living in North America. Since Hispanics represent an admixed population at high risk for cardiovascular diseases, in this study a Latin American population with a similar genetic background was assessed. To analyze a genetic association between CAV1 and metabolic traits in an admixed Latin American population. A cross-sectional study was carried out with adults from the Colombian Caribbean Coast, selected in urban clusters and work places through a stratified sampling to include diverse ages and socioeconomic groups. Blood pressure and waist circumference were registered. Serum concentrations of glucose, triglycerides, and high-density lipoprotein cholesterol were measured from an 8-hr fasting whole-blood sample. Two previously analyzed CAV1 single nucleotide polymorphisms were genotyped (rs926198 and rs11773845). A logistic regression model was applied to estimate the associations. An admixture adjustment was performed through a Bayesian model. A total of 605 subjects were included. rs11773845 was associated with hypertrig...Continue Reading

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Citations

Nov 17, 2020·Frontiers in Cell and Developmental Biology·Maria DudãuMihail E Hinescu
Oct 31, 2020·Molecular Biology Reports·Gabriela Montenegro de SouzaJaqueline de Azevêdo Silva
Jun 23, 2021·The British Journal of Nutrition·Faezeh Abaj, Khadijeh Mirzaei
Aug 7, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Atieh MirzababaeiKhadijeh Mirzaei

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Methods Mentioned

BETA
genotyping
PCR
three-hybrid
three hybrid

Software Mentioned

StepOne Real - Time PCR
STRAT
Haploview
R
haplo
stats R
Arlequin
LDheatmap
Genetic Power Calculator
Genetix

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