A Community-based Assessment of Skin Care, Allergies, and Eczema (CASCADE): an atopic dermatitis primary prevention study using emollients-protocol for a randomized controlled trial

Trials
Brian EichnerEric L Simpson

Abstract

Atopic dermatitis (AD) is a common, chronic skin disorder often beginning in infancy. Skin barrier dysfunction early in life serves as a central event in the pathogenesis of AD. In infants at high risk of developing AD, preventative application of lipid-rich emollients may reduce the risk of developing AD. This study aims to measure the effectiveness of this intervention in a population not selected for risk via a pragmatic, randomized, physician-blinded trial in the primary care setting. Infant-parent dyads are recruited from a primary care practice participating through one of four practice-based research networks in Oregon, Colorado, Wisconsin, and North Carolina. Eligible dyads are randomized to the intervention (daily use of lipid-rich emollient) or the control (no emollient) group (n = 625 infants in each) and are followed for 24 months. The primary outcome is the cumulative incidence of physician-diagnosed AD and secondary outcomes include caregiver-reported measures of AD and development of other atopic diseases. Data collection occurs via chart review and surveys, with no study visits required. Data will be analyzed utilizing intention-to-treat principles. AD is a common skin condition in infants that affects quality o...Continue Reading

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References

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Citations

Aug 21, 2020·Expert Opinion on Drug Delivery·Estefânia Vangelie Ramos CamposDaniele Ribeiro de Araujo
Feb 6, 2021·The Cochrane Database of Systematic Reviews·Maeve M KelleherRobert J Boyle
Feb 8, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Maeve M KelleherRobert J Boyle
Sep 22, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·L Techasatian, P Kiatchoosakun

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Software Mentioned

Meta
REDCap
LARC
PRECIS
REDCap ( Electronic Data Capture )
CASCADE

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.