A comparative analysis of clinicopathological features and survival among early adolescents/young adults and children with low-grade glioma: a report from the Children's Oncology Group

Journal of Neuro-oncology
Ashley S MargolGirish Dhall

Abstract

For several types of cancer, biological differences and outcome disparities have been documented in adolescents/young adults (AYAs, 15-39 years old) versus children. This study compared clinicopathological features and survival between younger AYAs and children with low-grade glioma (LGG), a common brain tumor among AYAs. This was a secondary analysis of Children's Oncology Group legacy study CCG-9891/POG-9130, which enrolled participants 0-21 years of age with newly-diagnosed LGG treated with surgery alone. For analysis, participants were categorized as children (0-14 years old) or early AYAs (eAYAs, 15-21 years old) and compared on demographics, clinical presentation, tumor characteristics, surgical outcomes, progression-free survival (PFS) and overall survival (OS). Among 468 children and 50 eAYAs, more eAYAs presented with seizures (34.0% vs. 19.2%; p = 0.015), without other significant differences in clinicopathological features. 5-year PFS rates for children and eAYA were 80.2% (95% confidence interval [95% CI], 76.1-83.7) and 83.0% (95% CI 68.8-91.1), respectively; 5-year OS rates were 97.3% (95% CI 95.2-98.5) and 95.4% (95% CI 82.7-98.8), respectively. Multivariable analysis including all participants showed presence of...Continue Reading

References

Feb 6, 2003·Cancer·Maryam FouladiRichard L Heideman
Jun 24, 2006·The Oncologist·Jeanine T Grier, Tracy Batchelor
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin S SmithMitchel S Berger
Apr 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Iyad SultanAndrea Ferrari
Nov 18, 2010·Neuro-oncology·Ryo Nishikawa
Nov 1, 2012·Neuro-oncology·Roberta RudàRiccardo Soffietti
Mar 5, 2014·Biochimica Et Biophysica Acta·Guillaume BergtholdMark W Kieran
Jan 20, 2015·Journal of Pediatric Surgery·Mary T AustinLinda S Elting
Feb 11, 2015·Advances in Anatomic Pathology·Sriram Venneti, Jason T Huse
May 29, 2016·The Journal of Pediatrics·Emma C HamiltonMary T Austin
Nov 2, 2016·Journal of Neurosurgery. Pediatrics·Mary T AustinDavid I Sandberg
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Alvaro LassalettaUri Tabori
Mar 16, 2017·Science Signaling·Kun-Wei LiuRobert J Wechsler-Reya
Oct 20, 2017·Pediatric Blood & Cancer·Michal ZapotockyEric Bouffet

❮ Previous
Next ❯

Citations

Apr 3, 2020·International Journal of Cancer. Journal International Du Cancer·Fabian FalkensteinTorsten Pietsch
Sep 23, 2020·Pediatric Blood & Cancer·Paul AridgidesDaphne Haas-Kogan
Sep 25, 2020·Journal of Neurological Surgery. Part A, Central European Neurosurgery·Johannes WachSevgi Sarikaya-Seiwert
Jun 1, 2021·Neuro-oncology Practice·Kee Kiat YeoDavid A Reardon
Jan 23, 2022·International Journal of Clinical Oncology·Fumiyuki Yamasaki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.