PMID: 9544955Apr 17, 1998Paper

A comparative analysis of lobular and ductal carcinoma of the breast: presentation, treatment, and outcomes

Journal of the American College of Surgeons
D J WinchesterD P Winchester

Abstract

Compared with invasive ductal carcinoma, invasive lobular carcinoma of the breast is considered by many to be a more indistinct and multicentric form of cancer that is detected later and is treated less optimally by breast-preservation techniques. This study analyzed the presentation, treatment trends, and survival rates of women who had invasive lobular and ductal breast carcinoma. The objective was to determine the utility of breast-preservation therapy for invasive lobular carcinoma by analysis of historic data on tumor features and survival. Data on 291,273 women diagnosed with invasive carcinoma between 1985 and 1993 were obtained from the National Cancer Data Base. Analysis included the patient's age at diagnosis; tumor histology, anatomic site, diameter, grade, and stage; treatment; and disease status 5 years after diagnosis. The mean patient age at diagnosis was 61.0 years for invasive ductal carcinoma, 63.0 years for invasive lobular carcinoma, and 60.6 years for tumors with combined histology. The anatomic location, tumor diameter, and tumor grade were similar for each histotype. Breast-preservation therapy was less frequent for invasive lobular carcinoma. The 5-year overall survival and local disease-free survival ra...Continue Reading

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Citations

Jul 17, 2008·Breast Cancer Research and Treatment·Giuseppe VialeAlan S Coates
Mar 23, 2004·Molecular Biology of the Cell·Hongjuan ZhaoStefanie S Jeffrey
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