A comparative analysis of quality of life data from a Southwest Oncology Group randomized trial of advanced colorectal cancer

Statistics in Medicine
Andrea B Troxel

Abstract

Longitudinal quality of life measurements from an advanced-stage cancer clinical trial are analysed using a variety of methods, and the results compared. The methods used require different assumptions about the mechanism that produces the missing data. They include analyses that require the data to be missing completely at random; fixed-effects models and weighted generalized estimating equations, which require missing at random data; and a fully parametric approach where the outcomes and the missingness mechanism are jointly modelled, allowing non-ignorable missing data. The data show evidence of non-random missingness, but a formal test of non-ignorable missing data is not significant.

Citations

Feb 13, 2009·Biometrics·Xiaoyan ShiJoseph G Ibrahim
Apr 28, 2010·Biometrical Journal. Biometrische Zeitschrift·Hui Xie
May 24, 2005·Statistics in Medicine·Guoguang MaDaniel F Heitjan
Jan 18, 2006·Statistics in Medicine·Joseph C GardinerCharles W Given
Sep 8, 2012·Health Services & Outcomes Research Methodology·Beth Ann GriffinMarika Suttorp
Oct 28, 1998·Journal of the National Cancer Institute·C M MoinpourF L Meyskens
Oct 27, 2004·Journal of the National Cancer Institute. Monographs·Dawn Provenzale, Rebecca N Gray

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