Abstract
There is a myriad of research in the pharmacological manipulation of skin flap survival. However, skepticism exists as to whether any of these drugs is clinically useful. We evaluated the efficacy of five categories of agents in improving skin flap survival in five different rat flap models. Diltiazem, isoxsuprine hydrochloride, nitroglycerin, prazosin hydrochloride (two doses), and methyldopa were compared in a double-blind, randomized fashion. Their benefits were assessed in a musculocutaneous flap, axial flap, and three types of random flaps. The "best" drug was determined to be nitroglycerin. Its efficacy was verified in a primate model.
Citations
Dec 10, 1998·Microsurgery·W K StadelmannD P Greenwald
Jan 1, 1994·Microsurgery·K R Knight
Jan 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y ChenR G Steen
Mar 1, 1995·British Journal of Plastic Surgery·M B HirigoyenH Weinberg
Jun 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M B HirigoyenM L Urken
May 18, 2007·Actas dermo-sifiliográficas·P Coto-SeguraM A Rodríguez-Prieto
May 4, 2001·Plastic and Reconstructive Surgery·A LoskenS A Slavin
Jan 16, 2016·BioMed Research International·Liu PengGuoqian Yin
Feb 13, 2007·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·J M LassoR Pérez Cano
Mar 1, 2005·The Journal of Surgical Research·Naci KaraçalNecmettin Kutlu
Jan 5, 2002·Annals of Plastic Surgery·Ashkan GhavamiStephen P Hardy
May 26, 2004·Microsurgery·Feng ZhangWilliam C Lineaweaver
Nov 25, 2000·Journal of Applied Physiology·J ZhangC Y Pang
Jul 23, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Can AtalayM Turan Akay
Oct 7, 2005·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Ali AyyildizMuzaffer Caydere
Sep 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·D K Smith, R W Dolan