PMID: 1292706Dec 1, 1992

A comparative analysis of the cerebral cortical proteins in rats with different sensitivities to hypoxia

Biulleten' eksperimental'noĭ biologii i meditsiny
L D Luk'ianova, V I Bogomolov


A comparative analysis of 339 protein fractions of cerebral cortex of rats both resistant and non-resistant to oxygen deficiency has been fulfilled by means of two-dimensional gel-electrophoresis. A specific group of 9 protein fractions with molecular weights in the range of 32-68 kD was found to be quantitatively changed under hypoxia influence. An activation of labile protein synthesis was a predominant response to acute hypoxia in the resistant rats, while the synthesizing processes in the non-resistant rats were rather weak. An adaptation to hypoxia mostly resulted in the decrease of quantitative representations of labile protein fractions and has been realizing in different ways in resistant and nonresistant rats. The data obtained seem to testify to the changes of protein synthesis under chronic hypoxia conditions in the cerebral cortex chiefly determined by fast adaptation mechanisms.

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