A comparative analysis of the cycle fecundity rates associated with combined human menopausal gonadotropin (hMG) and intrauterine insemination (IUI) versus either hMG or IUI alone

Fertility and Sterility
L M ChaffkinD A Metzger


Human menopausal gonadotropin (hMG) superovulation combined with washed intrauterine insemination (IUI) has been advocated for the treatment of various forms of infertility when more traditional therapy has failed. To assess the relative efficacy of combined treatment with hMG and IUI compared with either hMG or IUI alone, pregnancy outcomes of the three treatment groups were compared in couples having infertility because of male factor, cervical factor, endometriosis, or unexplained. A total of 751 cycles were analyzed from 322 couples. The mean cycle fecundity rate associated with hMG/IUI therapy was significantly higher than either hMG or IUI therapy alone for all patients (hMG/IUI = 19.6%, hMG = 6.3%, IUI = 3.4%). The improvement in cycle fecundity rates with hMG/IUI therapy was also observed when the couples were separated by infertility diagnostic groups: male factor (hMG/IUI = 15.3%, hMG = 4.4%, IUI = 3.0%), cervical factor (hMG/IUI = 26.3%, hMG = 7.9%, IUI = 5.1%), endometriosis (hMG/IUI = 12.85%, hMG = 6.6%), and unexplained infertility (hMG/IUI = 32.6%, hMG = 5.5%, IUI = 0%). Moreover, in patients who had failed to conceive with hMG or IUI alone, the cycle fecundity rate when they were switched to hMG/IUI therapy equa...Continue Reading


Jan 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·O GregoriouC Louridas
Feb 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·O GregoriouD Rizos
May 12, 2004·Fertility and Sterility·Practice Committee of the American Society for Reproductive Medicine
Sep 15, 2004·Fertility and Sterility·Practice Committee of the American Society for Reproductive Medicine
Aug 8, 1998·Fertility and Sterility·David S GuzickM P Steinkampf
Jul 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·S Nuojua-HuttunenH Martikainen
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·A Amar-HoffetJ Belaisch-Allart
Jan 7, 2003·The Journal of Obstetrics and Gynaecology Research·Lakhbir K DhaliwalS Majumdar
Jun 6, 1992·BMJ : British Medical Journal·M G HullA McDermott
Jan 1, 2010·Journal of Laboratory Physicians·Neha Agarwal, Arulselvi Subramanian
Feb 7, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·P J WoodwardT P Mezzetti
Jun 3, 2014·American Journal of Obstetrics and Gynecology·Randi H GoldmanJohn C Petrozza
Dec 6, 2019·Human Reproduction Update·N A DanhofM H Mochtar
Feb 9, 1999·Obstetrical & Gynecological Survey·F Zayed, A Abu-Heija
Dec 9, 2000·Current Opinion in Obstetrics & Gynecology·R P Buyalos, S K Agarwal
Sep 1, 1996·Journal of Assisted Reproduction and Genetics·D ValbuenaA Pellicer
Jan 1, 1996·Journal of Assisted Reproduction and Genetics·H Y HuangY K Soong
Mar 27, 2001·Acta Obstetricia Et Gynecologica Scandinavica·M R KhalilL G Westergaard
Oct 20, 2005·The Cochrane Database of Systematic Reviews·Frans M HelmerhorstDavid A Grimes
Feb 12, 2008·Human Reproduction·Inge M CustersBen W J Mol
Oct 1, 1992·Journal of Assisted Reproduction and Genetics·J C NulsenM M Steinhoff
Jun 1, 1995·International Journal of Andrology·A Mackenna
Nov 1, 1994·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·M G Hull
Dec 21, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Tom Tanbo, Peter Fedorcsak
Jun 17, 1993·The New England Journal of Medicine·D L Olive, L B Schwartz
Jul 1, 1993·Archives of Andrology·F M IrianniA A Acosta
May 25, 2006·Obstetrical & Gynecological Survey·Frans M HelmerhorstDavid A Grimes
Apr 30, 2008·Annals of the New York Academy of Sciences·Sebiha OzkanAydin Arici
May 2, 2003·Journal of Andrology·Jan Tesarik, Carmen Mendoza
Jun 21, 1993·The Medical Journal of Australia·A O Trounson, C Wood

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