A Comparative Benchmark Dose Study for N, N-Dimethylformamide Induced Liver Injury in a Chinese Occupational Cohort

Toxicological Sciences : an Official Journal of the Society of Toxicology
Zhijun WuJuan Cheng

Abstract

Widespread contamination of N,N-dimethylformamide (DMF) has been identified in the environment of leather industries and their surrounding residential areas. Few studies have assessed the dose-response relationships between internal exposure biomarkers and liver injury in DMF exposed populations. We assessed urinary N-methylformamide (NMF) and N-acetyl-S-(N-methylcarbamoyl) cysteine (AMCC) and blood N-methylcarbmoylated hemoglobin (NMHb) levels in 698 Chinese DMF-exposed workers and 188 nonDMF- exposed workers using ultraperformance liquid-chromatography tandem mass-spectrometry. Liver injury was defined as having abnormal serum activities of any of the 3 liver enzymes, including alanine aminotransferase, aspartate aminotransferase, and γ-glutamyl transpeptidase. Higher liver injury rates were identified in DMF-exposed workers versus nonDMF-exposed workers (9.17% vs 4.26%, P = .029) and in male versus female workers (11.4% vs 3.2%, P < .001). Positive correlations between environmental exposure categories and internal biomarker levels were identified with all 3 biomarkers undetectable in nonDMF-exposed workers. Lower confidence limit of benchmark dose (BMDL) was estimated using the benchmark dose (BMD) method. Within all study ...Continue Reading

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Citations

Mar 14, 2018·International Journal of Environmental Research and Public Health·Junghyun LeeSang-Hoon Byeon
Jul 10, 2018·Journal of Biochemical and Molecular Toxicology·Shiqing Li, Cui Wang
Jul 11, 2020·Journal of Applied Toxicology : JAT·Zhen ZhangQing Wang
Apr 18, 2019·International Archives of Occupational and Environmental Health·Haiyue JiangYulong Lian

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