A comparative chemical and pharmacological study of standardized extracts and vanillic acid from wild and cultivated Amburana cearensis A.C. Smith

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
L K LealG S Viana

Abstract

The objectives of this work were to carry out a comparative chemical study and to evaluate the antinociceptive and anti-inflammatory activities of ethanol extracts (EtOHE) and vanilic acid (VA) from cultivated and wild Amburana cearensis A.C. Smith (Fabaceae), an endangered species used in Northeast Brazil for the treatment of asthma. The HPLC analysis of EtOHE, showed that coumarin (CM) and VA were the major constituents from the cultivated plant, while in the extract from the wild plant the major constituents were amburoside A (AMB) and CM. Pharmacological tests were performed with male Swiss mice or male Wistar rats acutely administered with 100-400mg/kg, p.o. of EtOHEs or 12.5-50mg/kg, p.o. of VA. EtOHEs from A. cearensis with 4, 7 or 9 months of cultivation significantly inhibited, from 32 to 64%, both phases of the formalin test in mice. Similar results were observed with the EtOHE from the wild species. VA significantly reduced both phases of the formalin test. This effect was partially reversed by naloxone. EtOHE from cultivated or wild A. cearensis inhibited the carrageenan (Cg)-induced mice paw edema. Furthermore, VA inhibited the paw edema and the leukocyte migration in rat peritoneal cavity induced by Cg. On the oth...Continue Reading

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Sep 1, 1997·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·L K LealG S Viana

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Citations

Dec 5, 2014·Pharmaceutical Biology·Jayasingh Chellammal Hanish SinghPrakash Vamanrao Diwan
May 23, 2012·Journal of Ethnopharmacology·Florencia MorucciSusana Gorzalczany
Feb 26, 2015·Pharmacology, Biochemistry, and Behavior·María de Los Angeles YrbasSusana Gorzalczany
Jun 18, 2015·Zygote : the Biology of Gametes and Early Embryos·R S BarberinoM H T Matos

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