A comparative chemoreactome analysis of mexidol

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
I Yu TorshinL E Fedotova

Abstract

To compare mexidol with control molecules (choline alfoscerate, piracetam, glycine, semax) using chemoreactome analysis. The chemical structure of mexidol was compared to molecule metabolites extracted from the Human Metabolome Database (HMDB) and a drug database. More than 40 000 of metabolites from HMDB were used as a model of human metabolome. The chemoreactome analysis showed that mexidol may be (1) an agonist of acetylcholine and GABA-A receptors; (2) an anti-inflammatory agent, the effects of which are carried out by inhibiting the synthesis of pro-inflammatory prostaglandins; (3) a neurotrophic agent with neuroprotective properties; (4) a coagulation inhibitor; (5) a diabetes medication and (6) a hypolipidemic agent. Compared to 'control' molecules, mexidol has a more pronounced safety profile (a lower impact on serotonin, dopamine and adrenergic receptors, a lesser degree of interaction with the potassium channels of the heart, MAO and P450 cytochromes). The results of modeling allow to specify the mechanisms of action of mexidol at the molecular level.

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Citations

Dec 1, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A GromovaA G Nazarenko
Apr 21, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·I A StrelnikovaO V Androfagina
Oct 19, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·O A GromovaO V Tikhonova
Jun 12, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·D M PlotnikovO I Aliev

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