PMID: 6758831Oct 1, 1982Paper

A comparative double-blind study of the bronchodilator effects and side effects of inhaled fenoterol and terbutaline administered in equipotent doses

British Journal of Diseases of the Chest
B J GrayJ F Costello

Abstract

Increasing doses of fenoterol and terbutaline were administered by inhaler to 12 stable asthmatics in a double-blind crossover trial. 100 microgram doses of fenoterol were shown to be equal in potency to 250 microgram doses of terbutaline, as measured by increases in forced expiratory volume in the first second (FEV1) and specific airways conductance (sGaw). FEV1 and sGaw remained significantly greater than pretreatment levels up to five hours after both drugs and terbutaline showed a significantly greater effect on FEV1 than fenoterol after four hours suggesting a small but significantly longer duration of activity. Fenoterol used at the dosage of 100 micrograms per puff (half the standard commercially available dose of 200 micrograms per puff) caused significantly more cardiac effects than terbutaline, as measured by the magnitude and duration of increases in heart rate, and the incidence of reported palpitations.

Citations

Feb 1, 1992·British Journal of Clinical Pharmacology·B J Lipworth, D G McDevitt
Jul 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N PearceR Beasley
Oct 1, 1991·Australian and New Zealand Journal of Medicine·R BeasleyC Burgess
May 1, 1991·The American Review of Respiratory Disease·E H RamsdaleP M O'Byrne
Aug 1, 1991·The American Review of Respiratory Disease·H S NelsonR J Martin
Jul 1, 1990·Allergy·L B Ribeiro, J E Wirén
Mar 20, 2004·Journal of Cardiovascular Electrophysiology·Per InsulanderHans Vallin
May 23, 2012·Pharmacological Reviews·Mario CazzolaMaria G Matera
Jul 1, 1986·Medical Toxicology·K M LulichJ W Paterson
Jan 1, 1996·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·D M ScalabrinC K Naspitz

Related Concepts

Airway Resistance
Asthma
Clinical Trials
Dose-Response Relationship, Drug
Double-Blind Method
Ethanolamines
Fenoterol Hydrobromide
Forced Expiratory Volume Function
Respiratory Therapy
Terbutalin von ct

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