A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease

BioMed Research International
Iván CarreraCarmen Vigo

Abstract

Immunization against amyloid-beta-peptide (Aβ) has been widely investigated as a potential immunotherapeutic approach for Alzheimer's disease (AD). With the aim of developing an active immunogenic vaccine without need of coadjuvant modification for human trials and therefore avoiding such side effects, we designed the Aβ 1-42 vaccine (EB101), delivered in a liposomal matrix, that based on our previous studies significantly prevents and reverses the AD neuropathology, clearing Aβ plaques while markedly reducing neuronal degeneration, behavioral deficits, and minimizing neuroinflammation in APP/PS1 transgenic mice. Here, the efficacy of our immunogenic vaccine EB101 was compared with the original immunization vaccine cocktail Aβ 42 + CFA/IFA (Freund's adjuvant), in order to characterize the effect of sphingosine-1-phosphate (S1P) in the immunotherapeutic response. Quantitative analysis of amyloid burden showed a notable decrease in the neuroinflammation reaction against Aβ plaques when S1P was compared with other treatments, suggesting that S1P plays a key role as a neuroprotective agent. Moreover, EB101 immunized mice presented a protective immunogenic reaction resulting in the increase of Aβ-specific antibody response and decre...Continue Reading

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Citations

Apr 23, 2016·Vaccines·Abhishek Vartak, Steven J Sucheck
Jun 14, 2016·Pharmacogenomics·Ramón CacabelosJuan Carlos Carril
Mar 21, 2017·Biochimica Et Biophysica Acta. Biomembranes·Indulekha Karunakaran, Gerhild van Echten-Deckert
Jan 6, 2018·Journal of Personalized Medicine·Ramón CacabelosÓscar Teijido
May 8, 2020·International Journal of Molecular Sciences·Matteo BordoniCristina Cereda
Aug 1, 2021·Expert Opinion on Drug Discovery·Ramón CacabelosVinogran Naidoo

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Methods Mentioned

BETA
transgenic
ELISA
Flow Cytometric
flow cytometry

Software Mentioned

SPSS
NIH Image J
Pixcavator

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