PMID: 9637660Jun 24, 1998Paper

A comparative evaluation of the effects of multiple vasodilators on human internal mammary artery

Anesthesiology
C HurauxJ H Levy

Abstract

Vasospasm of arterial grafts represents an unpredictable complication of coronary artery surgery and may compromise myocardial revascularization, and treatment is based on empirical therapy with nitroglycerin. Because of the potential for tolerance to nitroglycerin to occur, the authors studied different vasodilators acting through separate pathways on segments of human internal mammary artery. Isolated vascular rings were precontracted with norepinephrine (1 microM), KCl, or the thromboxane A2 analogue (U46619, 10 nm). Nitroglycerin (a nitrovasodilator), milrinone (a type III phosphodiesterase inhibitor), papaverine (a phosphodiesterase inhibitor), prostaglandin E1, and isradipine (a dihydropyridine calcium channel blocker) were added in a cumulative fashion. The analysis of the concentration-response curves showed that vasodilators induced 90-100% relaxation of the constricted segments with norepinephrine or the thromboxane A2 analogue, except prostaglandin E1, which produced 73% relaxation at maximal concentrations. The effective concentrations of vasodilator agent that caused 50% relaxation for nitroglycerin and milrinone were within the range of the reported therapeutic concentrations in plasma. Isradipine was also effecti...Continue Reading

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Citations

Oct 15, 2009·Cardiovascular Drugs and Therapy·Hossein MirkhaniHajar Khazraei
Oct 24, 2006·Anesthesia and Analgesia·Félix R MontesJuan P Umaña
Jun 19, 2013·The Annals of Thoracic Surgery·Go WatanabeRyuta Kiuchi
Oct 7, 2004·The Annals of Thoracic Surgery·Dhru S GirardFred A Crawford
Feb 9, 2002·The Annals of Thoracic Surgery·Jerrold H LevyG Michael Deeb
Jun 2, 2007·Asian Cardiovascular & Thoracic Annals·Muzaffer BahcivanH Tahsin Keceligil

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