A comparative histological study of alginate beads as a promising controlled release delivery for mefenamic acid

Pharmaceutical Development and Technology
Ferhan SevgiDogan Ozyurt

Abstract

The new mefenamic acid-alginate bead formulation prepared by ionotropic gelation method using 3 x 2(2) factorial design has shown adequate controlled release properties in vitro. In the present study, the irritation effects of mefenamic acid (MA), a prominent non-steroidal anti-inflammatory (NSAI) drug, were evaluated on rat gastric and duodenal mucosa when suspended in 0.5% (w/v) sodiumcarboxymethylcellulose (NaCMC) solution and loaded in alginate beads. Wistar albino rats weighing 200 +/- 50 g were used during in vivo animal studies. In this work, biodegradable controlled release MA beads and free MA were evaluated according to the degree of gastric or duodenal damage following oral administration in rats. The gastric and duodenal mucosa was examined for any haemorrhagic changes. Formulation code A10 showing both Case II transport and zero order drug release and t(50) % value of 5.22 h was chosen for in vivo animal studies. For in vivo trials, free MA (100 mgkg(-1)), blank and MA (100 mgkg(-1)) loaded alginate beads (formulation code A10) were suspended in 0.5% (w/v) NaCMC solution and each group was given to six rats orally by gavage. NaCMC solution was used as a control in experimental studies. In vivo data showed that the ...Continue Reading

References

Feb 1, 1993·Journal of Pharmaceutical Sciences·R Bodmeier, J Wang
Jun 6, 2000·Advanced Drug Delivery Reviews·S Wee, W R Gombotz
Dec 14, 2002·Brain Research. Developmental Brain Research·Hong Peng LiYoshiki Takeuchi
Jul 16, 2005·Journal of Microencapsulation·B AricaA A Hincal
Aug 17, 2005·International Journal of Pharmaceutics·Pasquale Del GaudioFabio Sonvico
Oct 6, 2007·AAPS PharmSciTech·Pornsak Sriamornsak, Srisagul Sungthongjeen
Dec 29, 2007·Pharmaceutical Development and Technology·Go KimuraHans Leuenberger
Aug 24, 2010·AAPS PharmSciTech·Pornsak SriamornsakSomkamol Manchun

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Citations

Apr 22, 2011·Expert Opinion on Drug Delivery·Khosro AdibkiaYousef Javadzadeh
Mar 24, 2010·Pharmaceutical Development and Technology·Mona Hassan Aburahma, Yassin El-Said Hamza

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