A comparative magnetic resonance imaging study of the anatomy, variability, and asymmetry of Broca's area in the human and chimpanzee brain.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Simon S KellerWilliam D Hopkins

Abstract

The frontal operculum-classically considered to be Broca's area-has special significance and interest in clinical, cognitive, and comparative neuroscience given its role in spoken language and the long-held assumption that structural asymmetry of this region of cortex may be related to functional lateralization of human language. We performed a detailed morphological and morphometric analysis of this area of the brain in humans and chimpanzees using identical image acquisition parameters, image analysis techniques, and consistent anatomical boundaries in both species. We report great inter-individual variability of the sulcal contours defining the operculum in both species, particularly discontinuity of the inferior frontal sulcus in humans and bifurcation of the inferior precentral sulcus in chimpanzees. There was no evidence of population-based asymmetry of the frontal opercular gray matter in humans or chimpanzees. The diagonal sulcus was only identified in humans, and its presence was significantly (F = 12.782, p < 0.001) associated with total volume of the ipsilateral operculum. The findings presented here suggest that there is no population-based interhemispheric macroscopic asymmetry of Broca's area in humans or Broca's ...Continue Reading

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Citations

Mar 20, 2010·Proceedings. Biological Sciences·Muhammad A SpocterChet C Sherwood
Apr 26, 2013·Proceedings. Biological Sciences·Aida Gómez-RoblesChet C Sherwood
Nov 23, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·William D HopkinsJennifer A Schaeffer
Sep 3, 2010·Journal of Cognitive Neuroscience·Simon S KellerMichael Deppe
Mar 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William D Hopkins, Brian B Avants
Dec 3, 2015·Proceedings of the National Academy of Sciences of the United States of America·Aida Gómez-RoblesChet C Sherwood
Apr 10, 2012·Brain and Language·Joanne L PowellMarta García-Finaña
Dec 24, 2015·Journal of Cognitive Neuroscience·Michel BelykSteven Brown
Jan 31, 2015·Journal of Neurosurgery·John D RolstonMitchel S Berger
May 14, 2014·Frontiers in Human Neuroscience·Dean Falk
Nov 3, 2016·Social Cognitive and Affective Neuroscience·E E HechtW D Hopkins
Jan 28, 2016·Evolution; International Journal of Organic Evolution·Elizabeth G AtkinsonJames M Cheverud
Aug 10, 2011·The Journal of Comparative Neurology·Simon S KellerEmmanuel Gilissen
Feb 26, 2013·Evolutionary Anthropology·Christoph Peter Eduard Zollikofer, Marcia Silvia Ponce De León
Mar 27, 2013·Wiley Interdisciplinary Reviews. Cognitive Science·Jon H Kaas
Jan 13, 2019·Brain Structure & Function·Li XiangNeil Roberts
Oct 15, 2020·Scientific Reports·Jacob A MillerKevin S Weiner
Mar 4, 2021·Journal of Cognitive Neuroscience·Jacob A MillerKevin S Weiner
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Aug 15, 2021·Brain Structure & Function·Trisanna Sprung-MuchMichael Petrides
Dec 4, 2010·Neuroscience and Biobehavioral Reviews·David Borsook, Lino Becerra
Sep 29, 2011·Developmental Biology·Caleb A DollJoshua T Gamse

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