A comparative map of macroautophagy and mitophagy in the vertebrate eye.

Autophagy
Thomas G McWilliamsIan G Ganley

Abstract

Photoreception is pivotal to our experience and perception of the natural world; hence the eye is of prime importance for most vertebrate animals to sense light. Central to visual health is mitochondrial homeostasis, and the selective autophagic turnover of mitochondria (mitophagy) is predicted to play a key role here. Despite studies that link aberrant mitophagy to ocular dysfunction, little is known about the prevalence of basal mitophagy, or its relationship to general autophagy, in the visual system. In this study, we utilize the mito-QC mouse and a closely related general macroautophagy reporter model to profile basal mitophagy and macroautophagy in the adult and developing eye. We report that ocular macroautophagy is widespread, but surprisingly mitophagy does not always follow the same pattern of occurrence. We observe low levels of mitophagy in the lens and ciliary body, in stark contrast to the high levels of general MAP1LC3-dependent macroautophagy in these regions. We uncover a striking reversal of this process in the adult retina, where mitophagy accounts for a larger degree of the macroautophagy taking place, specifically in the photoreceptor neurons of the outer nuclear layer. We also show the developmental regula...Continue Reading

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Citations

Jul 28, 2020·Molecular and Cellular Biochemistry·Guadalupe Martínez-ChacónAlberto Ballestín
Apr 10, 2020·Neuronal Signaling·Fumi Suomi, Thomas G McWilliams
Mar 14, 2020·International Journal of Molecular Sciences·Ines RosignolPatricia Boya
Apr 17, 2020·Progress in Retinal and Eye Research·Kai KaarnirantaDeborah Ferrington
Mar 7, 2021·Life·José A Fernández-AlbarralAna I Ramírez
Mar 17, 2021·Investigative Ophthalmology & Visual Science·Jessica M SkeieMark A Greiner
Mar 27, 2021·Biochemical Society Transactions·Francois Singh, Ian G Ganley
Feb 23, 2020·Mechanisms of Ageing and Development·Konstantinos Palikaras, Nektarios Tavernarakis
Jun 15, 2021·Frontiers in Pharmacology·Daowei ZhangShenghai Zhang
Nov 3, 2021·EMBO Molecular Medicine·Jack J CollierRobert W Taylor
Jan 15, 2022·Cell Metabolism·Takayuki MitoAnu Suomalainen

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Methods Mentioned

BETA
biopsies
electron microscopy
PCR
biopsy

Software Mentioned

Prism
Adobe Photoshop
QC
ZEISS Zen
Imaris
Volocity
mito
GraphPad

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