PMID: 7028794Jan 1, 1981Paper

A comparative review of the pharmacological and toxicological properties of disulfiram and calcium carbimide

Journal of Clinical Psychopharmacology
J E PeacheyC W Loomis

Abstract

Disulfiram and calcium carbimide are widely used alcohol deterrents. Their safe use, however, requires a knowledge of their pharmacology, toxicity, and interactions with alcohol and other drugs. The absorption, metabolism, and elimination of these compounds are described, and elimination of these compounds are described, as is the mechanism of their reaction with ethanol. The effects and limitations of the interaction between ethanol and disulfiram and calcium carbimide are discussed. Four areas of concern regarding toxicity are discussed, including medical complications of the reactions with alcohol, toxicity associated with repeated doses of disulfiram or calcium carbimide, possible interactions with other drugs, and acetaldehyde-induce hepatotoxicity and cardiotoxicity.

Citations

Jan 1, 1981·Pharmacology & Therapeutics·J E Peachey, E M Sellers
Nov 19, 1981·The New England Journal of Medicine·E M SellersJ E Peachey
Aug 1, 1993·Journal of Toxicology and Environmental Health·M R Stein, L D Trombetta
Apr 1, 1983·Journal of Clinical Pathology·V Marks
Sep 21, 2013·Indian Journal of Psychological Medicine·Ranganath R Kulkarni, Bhavya K Bairy
May 12, 2009·Medicina clínica·Camilo González FernándezJuan Carlos Rodríguez Borregán
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Mar 12, 1999·Contact Dermatitis·P AbajoA García-Díez
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Jun 23, 1986·The Medical Journal of Australia·A Foy

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