A comparative study between oral melatonin and oral midazolam on preoperative anxiety, cognitive, and psychomotor functions

Journal of Anaesthesiology, Clinical Pharmacology
Tushar Patel, Madhuri S Kurdi

Abstract

Melatonin, a naturally occurring hormone in the human body, has been reported to cause preoperative anxiolysis and sedation without impairing orientation. The aim of the following study was to evaluate and to compare the effects of oral melatonin and oral midazolam on preoperative anxiety, sedation, psychomotor, and cognitive function. A study conducted on 120 patients aged 16-55 years, of American Society of Anesthesiologists Grade 1 and 2 posted for elective surgery, with each group of melatonin, midazolam, and placebo comprising 40 patients. Patients were given either 0.4 mg/kg oral melatonin or 0.2 mg/kg oral midazolam or a placebo 60-90 min before induction. Preoperative anxiety was studied before and 60-90 min after giving medications using visual analog scale (VAS) anxiety score, orientation score, and sedation score. Psychomotor and cognitive functions were studied using the digit symbol substitution test (DSST) and trail making test (TMT) tests. Data were analyzed using Chi-square test or Kruskal-Wallis analysis of variance and the value of P < 0.05 was considered as statistically significant. Changes in VAS anxiety scores were significant when melatonin was compared with placebo (P = 0.0124) and when midazolam was com...Continue Reading

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Citations

Nov 26, 2015·Journal of Biological Research·Mercedes Perez-HerediaLeticia Marchena-Rodríguez
Oct 28, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Israel Grilo BensusanMaría Valle Aguado Álvarez
Dec 19, 2019·Chronobiology International·Susana Barbosa-Méndez, Alberto Salazar-Juarez
Aug 28, 2018·Current Developmental Disorders Reports·Katia Gagnon, Roger Godbout
May 26, 2017·European Journal of Pediatrics·Pietro ImpellizzeriCarmelo Romeo
Dec 16, 2020·The Cochrane Database of Systematic Reviews·Bennedikte K MadsenJacob Rosenberg
May 26, 2021·Journal of Psychosomatic Research·Xi-Rong LiJian-Xiong An

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Methods Mentioned

BETA
sedation

Software Mentioned

DSST
SPSS

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