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A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer's Disease

Journal of Alzheimer's Disease : JAD

May 11, 2016

Ewelina Maliszewska-CynaIsabelle Aubert

Abstract

Evidence suggests that physical exercise can serve as a preventive strategy against Alzheimer's disease (AD). In contrast, much less is known about the impact of exercise when it is introduced after cognitive deficits are established. Using the TgCRND8 mouse model of amyloidosis, we com...read more

Mentioned in this Paper

Biological Markers
Spatial Memory
Familial Alzheimer Disease (FAD)
APP protein, human
Amyloidosis
Neurons
Curiosity
Plaque, Amyloid
Alzheimer's Disease
Plants, Transgenic
1
30
Paper Details
References
  • References66
  • Citations3
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  • References66
  • Citations3
1

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A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer's Disease

Journal of Alzheimer's Disease : JAD

May 11, 2016

Ewelina Maliszewska-CynaIsabelle Aubert

PMID: 27163797

DOI: 10.3233/jad-150660

Abstract

Evidence suggests that physical exercise can serve as a preventive strategy against Alzheimer's disease (AD). In contrast, much less is known about the impact of exercise when it is introduced after cognitive deficits are established. Using the TgCRND8 mouse model of amyloidosis, we com...read more

Mentioned in this Paper

Biological Markers
Spatial Memory
Familial Alzheimer Disease (FAD)
APP protein, human
Amyloidosis
Neurons
Curiosity
Plaque, Amyloid
Alzheimer's Disease
Plants, Transgenic
1
30

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Limbic System

The limbic system is comprised of several different parts of the brain involved in emotion, motivation, learning, and memory. Discover the latest research on the limbic system here.

Neurotoxicity, Inflammation & Neuroprotection

The end result of the inflammatory process, neurotoxicity and/or neuroprotection, is a function of the fine balance between the two cellular systems, i.e., of the complex signaling relationships between anti-inflammatory neuroprotective factors (neurotrophins and other chemical mediators) and proinflammatory neurotoxic factors (tnf, free radicals, certain cytokines, etc). Here are the latest discoveries pertaining to neurotoxicity, inflammation and neuroprotection.

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Paper Details
References
  • References66
  • Citations3
12345...
  • References66
  • Citations3
1
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