A comparative study for the inactivation of multidrug resistance bacteria using dielectric barrier discharge and nano-second pulsed plasma

Scientific Reports
Ji Hoon ParkPankaj Attri

Abstract

Bacteria can be inactivated through various physical and chemical means, and these have always been the focus of extensive research. To further improve the methodology for these ends, two types of plasma systems were investigated: nano-second pulsed plasma (NPP) as liquid discharge plasma and an Argon gas-feeding dielectric barrier discharge (Ar-DBD) as a form of surface plasma. To understand the sterilizing action of these two different plasma sources, we performed experiments with Staphylococcus aureus (S. aureus) bacteria (wild type) and multidrug resistant bacteria (Penicillum-resistant, Methicillin-resistant and Gentamicin-resistant). We observed that both plasma sources can inactivate both the wild type and multidrug-resistant bacteria to a good extent. Moreover, we observed a change in the surface morphology, gene expression and β-lactamase activity. Furthermore, we used X-ray photoelectron spectroscopy to investigate the variation in functional groups (C-H/C-C, C-OH and C=O) of the peptidoglycan (PG) resulting from exposure to plasma species. To obtain atomic scale insight in the plasma-cell interactions and support our experimental observations, we have performed molecular dynamics simulations to study the effects of p...Continue Reading

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Citations

Apr 6, 2016·Archives of Biochemistry and Biophysics·N Mohd NasirS L Yap
May 25, 2016·Archives of Biochemistry and Biophysics·Ryugo TeroMasafumi Ito
Oct 16, 2016·Scientific Reports·Xing-Quan WangKostya Ken Ostrikov
Feb 15, 2018·Scientific Reports·Pankaj AttriMasaharu Shiratani
Nov 16, 2016·Oncotarget·Dayun YanMichael Keidar
Aug 2, 2017·Physical Chemistry Chemical Physics : PCCP·Pankaj AttriMasaharu Shiratani
Jul 1, 2017·Biomedical Optics Express·Jae-Sun ChoiHun-Kuk Park
Jul 28, 2018·Scientific Reports·Priyanka ShawPankaj Attri
Aug 30, 2019·Materials·Fatemeh RezaeiNathalie De Geyter

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Methods Mentioned

BETA
X-ray
PCR
Assay

Software Mentioned

ReaxFF
OZONE

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