PMID: 3743887Sep 1, 1986Paper

A comparative study of adenylate cyclase activity and progesterone synthesis in ovine corpora lutea stimulated by different chemical derivatives or natural analogs of ovine LH

Molecular and Cellular Endocrinology
H JammesC Hermier

Abstract

The adenylate cyclase activation by ovine native LH, natural analogs (porcine LH, hCG) and chemical derivatives of LH (methylated, ethylated, isopropylated, guanidinated) was studied in purified plasma membranes of ovine corpora lutea, including the regulatory effects of guanyl 5'-yl imidophosphate (Gpp(NH)p) and Mg2+. The Ka app. for native LH (about 15 nM) was independent of Gpp(NH)p and Mg2+. Similar maximal activation of the enzyme was obtained by using ovine LH or natural analogs, but differences were remarked concerning the Ka app. values of these hormones. Porcine LH was equipotent with ovine LH; on the contrary, hCG exhibited a lower Ka app. value (3 nM). All chemical derivatives (Me-LH, Et-LH, Iso-LH and Gu-LH) exhibited Ka app. higher than native (about 2- to 4-fold), but similar maximal activation. No modification was observed in the regulatory effects of Gpp(NH)p and Mg2+ on the adenylate cyclase activation as a consequence of structural modifications of the hormone. A comparison of the steroidogenic activity on intact luteal cells and the adenylate cyclase activation ability on purified plasma membranes of the derivatives mentioned above evidenced some interesting discrepancies. The drop in adenylate cyclase activa...Continue Reading

References

Sep 1, 1978·Molecular and Cellular Endocrinology·Y MintzY Salomon
Jan 1, 1975·Endocrine Research Communications· Liu W-KD N Ward
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·M L DufauK J Catt
Jul 12, 1979·Biochemical and Biophysical Research Communications·B B Aggarwal, H Papkoff
Aug 15, 1973·Nature: New Biology·K J Catt, M L Dufau
Feb 1, 1980·Acta Endocrinologica·M P de la Llosa-HermierP de la Llosa
Apr 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·R J BourdageG D Niswender
Sep 1, 1982·Molecular and Cellular Endocrinology·H J van der MolenF F Rommerts
Feb 1, 1981·Endocrinology·P L Hwang, R J Ryan

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Citations

Aug 1, 1996·European Journal of Epidemiology·M M Morales Suarez-VarelaM C Jiménez López
Oct 27, 2017·Expert Review of Hematology·Vincenzo De SanctisChristos Kattamis
Jan 1, 1989·Toxicologic Pathology·J J Heindel, K A Treinen

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