A comparative study of age-related brain pathology--are neurodegenerative diseases present in nonhuman animals ?

Medical Hypotheses
Hiroyuki NakayamaKunio Doi

Abstract

Although some aged dogs definitely have dementia-like conditions, they have rather different brain histopathology from that seen in Alzheimer's disease including the shape of senile plaques, severity of neuron loss and absence of neurofibrillary tangles. Aged wild-type mice never show such brain lesions at all. In addition, no cases of Parkinson's disease have been reported in nonhuman animals yet. The reason for this might be non-parallel aging of the whole body and brain. If such nonhuman animals had a longer life span, like humans, typical Alzheimer's and Parkinson's lesions would be formed in the brain. As the rate of deposition of the misfolded proteins causing the lesions might be slow, nonhuman animals normally die before the lesions appear.

References

Jun 1, 1990·Nihon juigaku zasshi. The Japanese journal of veterinary science·K UchidaN Goto
Nov 1, 1988·Journal of Neuropathology and Experimental Neurology·L C CorkD L Price
Jan 1, 1996·Acta Neuropathologica·S NakamuraN Goto
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May 25, 2002·Neuromolecular Medicine·Kumar SambamurtiDebomoy K Lahiri
Jan 30, 2003·The EMBO Journal·Piero Andrea TemussiAnnalisa Pastore
Mar 5, 2003·Annals of Internal Medicine·Christopher M Clark, Jason H T Karlawish

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Citations

May 12, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·James K ChambersHiroyuki Nakayama
Mar 1, 2016·Neurobiology of Aging·Benhong XuChao Ma
Aug 8, 2015·Journal of Neuropathology and Experimental Neurology·Franziska SchmidtAlexandra Stolzing
Dec 2, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Geoffrey G MurphyAlcino J Silva
Jun 17, 2015·Oxidative Medicine and Cellular Longevity·Mariarita Romanucci, Leonardo Della Salda

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