A comparative study of albendazole and mebendazole-induced, time-dependent oxidative stress

Redox Report : Communications in Free Radical Research
C LocatelliDanilo Wilhelm-Filho

Abstract

Albendazole (ABZ) and mebendazole (MBZ) are two benzimidazole-derived drugs that show remarkable antihelmintic activity and are widely used in the treatment and control of helminths. Some antihelmintic drugs seem to act through the deleterious generation of reactive oxygen and nitrogen species (ROS and RNS, respectively) to which helminths have no, or relatively low, antioxidant defences (AD), when compared to aerobic organisms. The main objective of the present study consisted of the evaluation of the effect of both drugs on the AD and on some oxidative stress indicators in the host liver. Adult, male, Wistar rats were treated with ABZ or MBZ at doses of 40 mg/kg for different periods of time (2, 4, 8 and 10 days). After treatment, the activities of superoxide dismutase, catalase, glutathione reductase, and glutathione S-transferase, as well as the concentrations of TBARS, reduced glutathione, oxidized glutathione and total glutathione, were evaluated in rat hepatocytes. The serum nitrogen monoxide, usually known as nitric oxide (NO) levels, was also measured. The results showed that both drugs provoked an oxidative stress condition, demonstrated through the elevation of TBARS contents and through the decrease of some AD. More...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1978·International Review of Cytology·N S Kosower, E M Kosower
Jan 1, 1990·Chemico-biological Interactions·R Docampo
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Jan 1, 1984·Methods in Enzymology·L Flohé, F Otting
Jan 1, 1984·Methods in Enzymology·H Aebi
Apr 29, 1983·Science·A Meister
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 1, 1993·Critical Reviews in Toxicology·J P Kehrer
Jun 26, 1998·Free Radical Biology & Medicine·Y SagaraP Maher
Oct 20, 2001·Redox Report : Communications in Free Radical Research·R C PedrosaD Wilhelm Filho
Aug 1, 1988·Parasitology Today·H L CallahanE R James
Apr 1, 1990·Parasitology Today·E Lacey

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Citations

Mar 7, 2007·Archives of Toxicology·Yasuaki DewaKunitoshi Mitsumori
Aug 30, 2008·Archives of Toxicology·Yasuaki DewaKunitoshi Mitsumori
Oct 19, 2013·Journal of Cancer Research and Clinical Oncology·Peter NygrenRolf Larsson
Mar 26, 2016·Frontiers in Pharmacology·Shota SasagawaToshio Tanaka
Aug 25, 2015·Frontiers in Microbiology·Rodrigo Martínez-EspinosaGuadalupe Ortega-Pierres
Sep 11, 2007·FEMS Microbiology Letters·Karina Penedo Carvalho, Ana Paula Rocha Gadelha
Oct 7, 2016·Redox Biology·L S E P W CastroR C Pedrosa
Apr 15, 2014·Polish Journal of Veterinary Sciences·A Spodniewska
Aug 31, 2006·Phytotherapy Research : PTR·Víctor D SzewczukAlicia B Pomilio
Jul 4, 2020·Molecular and Biochemical Parasitology·Saptarshi RoyLarisha M Lyndem

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