Abstract
Albendazole (ABZ) and mebendazole (MBZ) are two benzimidazole-derived drugs that show remarkable antihelmintic activity and are widely used in the treatment and control of helminths. Some antihelmintic drugs seem to act through the deleterious generation of reactive oxygen and nitrogen species (ROS and RNS, respectively) to which helminths have no, or relatively low, antioxidant defences (AD), when compared to aerobic organisms. The main objective of the present study consisted of the evaluation of the effect of both drugs on the AD and on some oxidative stress indicators in the host liver. Adult, male, Wistar rats were treated with ABZ or MBZ at doses of 40 mg/kg for different periods of time (2, 4, 8 and 10 days). After treatment, the activities of superoxide dismutase, catalase, glutathione reductase, and glutathione S-transferase, as well as the concentrations of TBARS, reduced glutathione, oxidized glutathione and total glutathione, were evaluated in rat hepatocytes. The serum nitrogen monoxide, usually known as nitric oxide (NO) levels, was also measured. The results showed that both drugs provoked an oxidative stress condition, demonstrated through the elevation of TBARS contents and through the decrease of some AD. More...Continue Reading
References
Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jan 1, 1978·International Review of Cytology·N S Kosower, E M Kosower
Jan 1, 1990·Chemico-biological Interactions·R Docampo
Jan 1, 1985·Methods in Enzymology·I Carlberg, B Mannervik
Mar 1, 1969·Analytical Biochemistry·F Tietze
Jan 1, 1984·Methods in Enzymology·L Flohé, F Otting
Nov 1, 1984·Biochemical Pharmacology·M DubinA O Stoppani
Jan 1, 1984·Methods in Enzymology·H Aebi
Apr 29, 1983·Science·A Meister
Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 1, 1993·Critical Reviews in Toxicology·J P Kehrer
May 1, 1997·Drugs·N de SilvaD Bundy
Jun 26, 1998·Free Radical Biology & Medicine·Y SagaraP Maher
Sep 19, 1998·Free Radical Biology & Medicine·D A Wink, J B Mitchell
Sep 29, 1999·Journal of Neurochemistry·A GuidarelliO Cantoni
May 10, 2001·Archives of Medical Research·T RamírezL A Herrera
Oct 20, 2001·Redox Report : Communications in Free Radical Research·R C PedrosaD Wilhelm Filho
May 15, 2003·Acta Tropica·A D Dayan
Aug 1, 1988·Parasitology Today·H L CallahanE R James
Apr 1, 1990·Parasitology Today·E Lacey
Citations
Mar 7, 2007·Archives of Toxicology·Yasuaki DewaKunitoshi Mitsumori
Aug 30, 2008·Archives of Toxicology·Yasuaki DewaKunitoshi Mitsumori
Oct 19, 2013·Journal of Cancer Research and Clinical Oncology·Peter NygrenRolf Larsson
Feb 2, 2016·International Journal of Pharmaceutics·Atif ZafarMasood Ahmad
Aug 1, 2009·Toxicology·Meilan JinKunitoshi Mitsumori
Mar 26, 2016·Frontiers in Pharmacology·Shota SasagawaToshio Tanaka
Aug 25, 2015·Frontiers in Microbiology·Rodrigo Martínez-EspinosaGuadalupe Ortega-Pierres
Dec 2, 2011·Veterinary Parasitology·Blagoje DimitrijevićSrđan Stojanović
Sep 11, 2007·FEMS Microbiology Letters·Karina Penedo Carvalho, Ana Paula Rocha Gadelha
Oct 7, 2016·Redox Biology·L S E P W CastroR C Pedrosa
Apr 15, 2014·Polish Journal of Veterinary Sciences·A Spodniewska
Aug 31, 2006·Phytotherapy Research : PTR·Víctor D SzewczukAlicia B Pomilio
Oct 19, 2016·Journal of Aquatic Animal Health·Christopher Didigwu NwaniBridget Chidi A Ezeibe
Jul 4, 2020·Molecular and Biochemical Parasitology·Saptarshi RoyLarisha M Lyndem
Apr 5, 2021·Experimental Parasitology·Essia SebaiHafidh Akkari
Nov 23, 2020·Acta Tropica·Dalia A ElmehyGhada A Gamea