A comparative study of alpha2- and beta-adrenoceptor distribution in pigeon and chick brain

The European Journal of Neuroscience
A Fernández-LópezA Pazos

Abstract

The pharmacological properties and anatomical distribution of alpha2-, beta1- and beta2-adrenoceptors in pigeon and chick brains were studied by both homogenate binding and tissue section autoradiography. [3H]Bromoxidine (alpha2-adrenoceptor-), [3H]CGP 12177 (beta-adrenoceptor) and [125I]cyanopindolol (beta-adrenoceptor) were used as radioligands. In both species, [3H]bromoxidine binding to avian brain tissue showed a pharmacological profile similar to that previously reported for alpha2-adrenoceptors in mammals. Regarding the anatomical distribution, the areas with the highest densities of alpha2-adrenoceptors in the pigeon brain included the hyperstriatum, nuclei septalis, tectum opticum and some brainstem nuclei. Most beta-adrenoceptors found in tissue membranes and sections from chick and pigeon brain were of the beta2 subtype, in contrast to what has been reported in the mammalian brain, where the beta1 subtype is predominant. A striking difference was found between the two species regarding the densities of these receptors: while pigeon brain was extremely rich in [125I]cyanopindolol binding throughout the brain (mainly cerebellum) in the pigeon, the levels of labelling in the chick brain were much lower; the exception wa...Continue Reading

References

May 5, 1979·Brain Research·W J NicklasS Berl
Jan 1, 1978·Brain, Behavior and Evolution·P F Krayniak, A Siegel
Feb 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D B Bylund
Oct 15, 1990·The Journal of Comparative Neurology·T Shimizu, H J Karten
Nov 27, 1990·Neuroscience Letters·A Fernández-LópezA Pazos
Nov 1, 1989·Naunyn-Schmiedeberg's Archives of Pharmacology·C WaeberJ M Palacios
Aug 29, 1989·European Journal of Pharmacology·F De PaermentierR W Horton
Jul 1, 1989·Journal of Neuroscience Research·C R Dermon, E D Kouvelas
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R A BondD E Clarke
Jan 26, 1988·Brain Research·M M Dietl, J M Palacios
Nov 1, 1985·Journal of Pharmacological Methods·G A McPherson
Jan 1, 1967·Biochimica Et Biophysica Acta·M Yoshikawa-Fukada
Oct 1, 1966·Brain Research·H J Karten, A M Revzin
Apr 1, 1967·Journal of Gerontology·M Yoshikawa, S Hirai
Apr 1, 1967·The Journal of Physiology·A V Juorio, M Vogt
Jan 1, 1983·Journal of Receptor Research·M Staehelin, C Hertel
Nov 1, 1980·British Journal of Pharmacology·K Hirai, K Koketsu
Jan 1, 1981·Annual Review of Neuroscience·R G Northcutt
Oct 1, 1967·British Journal of Pharmacology and Chemotherapy·T B Bolton
Jan 1, 1982·Neurochemistry International·J Palacios, M J Kuhar

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Citations

Dec 5, 1998·Brain Research. Developmental Brain Research·R RevillaA Fernández-López
Sep 18, 2002·Progress in Neurobiology·Marie E Gibbs, Roger J Summers
Dec 16, 1998·Neuroscience Letters·V RevillaA Fernández-López
Sep 2, 1999·Neuroscience Letters·V RevillaA Fernández-López
Apr 26, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E OphirJ Marder
Apr 25, 2000·Brain Research. Brain Research Protocols·R RevillaA Fernández-López
Feb 8, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie E GibbsRoger J Summers
Dec 15, 2004·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Eshel OphirJacob Marder
Feb 27, 2008·The Journal of Comparative Neurology·Konstantinos AmpatzisCatherine R Dermon
Oct 17, 2008·The Journal of Comparative Neurology·Charlotte A Cornil, Gregory F Ball
Feb 27, 2010·The Journal of Comparative Neurology·Konstantinos Ampatzis, Catherine R Dermon
Mar 29, 2019·The Journal of Comparative Neurology·Claudio V MelloPeter V Lovell
Oct 25, 2017·The Journal of Comparative Neurology·Christina HeroldKarl Zilles

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