PMID: 589875Nov 1, 1977

A comparative study of antipyrine pharmacokinetics in saliva and plasma using a colourimetric method of antipyrine analysis

Clinical and Experimental Pharmacology & Physiology
A E HarmanD B Frewin

Abstract

1. Half-life, apparent volume of distribution and metabolic clearance rate for antipyrine elimination were reliably estimated from either plasma or saliva samples. 2. Pharmacokinetic analysis of antipyrine from saliva utilizing a simple and sensitive colourimetric technique provided a convenient method for assessing the activity of hepatic microsomal drug-metabolizing enzymes.

References

Nov 1, 1975·Clinical Pharmacology and Therapeutics·T Inaba, W Kalow
Feb 6, 1976·European Journal of Clinical Pharmacology·C J van BoxtelF Sjöqvist
Apr 1, 1976·British Journal of Clinical Pharmacology·H S FraserD S Davies
Sep 1, 1975·Clinical Pharmacology and Therapeutics·R M WelchT W Farmer
Sep 1, 1975·Clinical Pharmacology and Therapeutics·E S VesellB H Dvorchik
Oct 1, 1975·Clinical Pharmacology and Therapeutics·R E VestalR Andres
Dec 1, 1975·Journal of Pharmacokinetics and Biopharmaceutics·H G BoxenbaumS A Kaplan
Nov 1, 1975·Clinical and Experimental Pharmacology & Physiology·D E LiddellR H Briant
Jul 17, 1976·British Medical Journal·P HartL W Powell
Dec 1, 1974·Clinical Pharmacology and Therapeutics·S B MatinJ H Karam
Nov 30, 1974·British Medical Journal·J A ForrestI H Stevenson
Nov 2, 1972·The New England Journal of Medicine·E S Vesell
Jan 1, 1974·Clinical Pharmacology and Therapeutics·D E CarterM W Heine
Aug 1, 1972·Journal of Pharmaceutical Sciences·G Graham, M Rowland
Jul 5, 1968·Science·E S Vesell, J G Page

Citations

Jan 1, 1983·Clinical and Experimental Pharmacology & Physiology·K V MuraliS Chandrasekar

Related Concepts

Pyramidone
Colorimetry
Half-Life
Saliva

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