A comparative study of aqueous and organic-based films and coatings of PEGylated rosin derivative

Drug Development and Industrial Pharmacy
Dinesh M MorkhadeSiddheshwar B Joshi

Abstract

Rosin was partially esterified with polyethylene glycol 400 and reacted with maleic-anhydride to form an ester-adduct derivative. Derivative and native rosin were characterized for physicochemical properties. Aqueous coating system of derivative was developed by ammonia neutralization method. Organic-based films were produced using acetone. Aqueous and organic-based films were comparatively evaluated. Derivative exhibited an excellent coat-forming ability on spherical-units. Aqueous-based film exhibited very high water vapor transmission rate, wettability, water uptake, and leaching at pH 6.8. A 20% w/w aqueous-based coat could sustain diclofenac sodium release for 8 h, whereas, 20% w/w organic-based coat released 20.11% of drug in 8 h. In conclusion, aqueous coating system of synthesized rosin derivative can be developed; however, aqueous-coats are less efficient to retard the drug release rate. Instead, the organic-based coatings can efficiently be used for sustained drug delivery.

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Citations

Jul 1, 2009·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Amitava RoyM E Bhanoji Rao
Dec 27, 2017·Drug Development and Industrial Pharmacy·Dinesh M MorkhadeSiddheshwar B Joshi
Jul 7, 2018·AAPS PharmSciTech·Yingjian Li, Dale Eric Wurster
May 2, 2021·International Journal of Pharmaceutics·Yingjian Li, Dale Eric Wurster

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