PMID: 375461Feb 1, 1979Paper

A comparative study of atropine methonitrate, salbutamol, and their combination in airways obstruction

Thorax
R J PierceA H Campbell

Abstract

Dose-response relationships of the cholinergic antagonist, atropine methonitrate, and the beta-adrenergic agonist, salbutamol, were examined by cumulative dose techniques. A wet aerosol, 1.5 mg atropine methonitrate produced a maximum response. The response to 200 microgram of salbutamol from a pressurised aerosol was close to maximum. Secondly, the bronchodilator response of salbutamol microgram was compared with atropine methonitrate 2 mg and placebo in 18 asthmatic patients in a randomised crossover study. In 11 of them the bronchodilator response of the combination of salbutamol and atropine methonitrate was evaluated. Atropine methonitrate produced a similar peak bronchodilator effect to salbutamol, but its effect was more prolonged, the response being significantly greater at four and six hours than with salbutamol. The combination of drugs produced a significantly greater and more lasting bronchodilatation than either of the drugs alone. Despite mild side effects, atropine methonitrate, either alone or in combination with an adrenergic drug, appears to have a place in the treatment of sever reversible airway obstruction not adequately controlled by conventional treatment.

References

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Citations

Jan 1, 1982·Pharmacology & Therapeutics·A E Tattersfield
Aug 16, 1984·The New England Journal of Medicine·N J Gross, M S Skorodin
Feb 21, 1981·British Medical Journal·M J WardD Davies
Dec 1, 1980·Thorax·C J Allen, A H Campbell
Feb 1, 1983·Thorax·M I UllahG J Addis
Jan 1, 1992·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C K Naspitz, D Sole
Jul 1, 1992·Respiratory Medicine·B R O'DriscollA Bernstein
Apr 1, 1986·British Journal of Diseases of the Chest·L A Laitinen, H Poppius
Apr 1, 1983·British Journal of Diseases of the Chest·B C LeahyS C Allen
Jul 1, 1985·British Journal of Diseases of the Chest·J S Mann, C F George
Oct 21, 1991·The American Journal of Medicine·K R Chapman
Feb 1, 1982·Australian and New Zealand Journal of Medicine·R J PierceA H Campbell
May 23, 2012·Pharmacological Reviews·Mario CazzolaM Gabriella Matera
Jul 22, 2004·The Cochrane Database of Systematic Reviews·M WestbyP Gibson

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