PMID: 8946565Nov 1, 1996Paper

A comparative study of chemically induced DNA damage in isolated human and rat testicular cells

Reproductive Toxicology
C BjørgeE J Søderlund

Abstract

Testicular cells prepared from human organ transplant donors or from Wistar rats were used to compare 15 known reproductive toxicants with respect to their ability to induce DNA damage, measured as single-strand DNA breaks and alkali labile sites (ssDNA breaks) with alkaline filter elution. The compounds tested included various categories of chemicals (i.e., pesticides, industrial chemicals, cytostatics, and mycotoxins) most of which are directly acting genotoxicants (i.e., reacting with DNA either spontaneously or via metabolic activation). In addition, a few indirect genotoxic and nongenotoxic reproductive toxicants were included. Six of the chemicals induced no significant levels of ssDNA breaks in human and rat testicular cells; methoxychlor (10 to 100 microM, human and rat), benomyl (10 to 100 microM, human and rat), thiotepa (10 to 1000 microM, human and rat), cisplatin (30 to 1000 microM, human; 100 to 1000 microM, rat), Cd2+ (30 to 1000 microM, human; 100 to 1000 microM, rat), and acrylonitrile (30 to 1000 microM, human; 30 to 300 microM, rat). Four chemicals induced significant levels of ssDNA breaks in testicular cells from both species: styrene oxide (> or = 100 microM, rat and human), 1,2-dibromoethane (EDB) (> or =...Continue Reading

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