A comparative study of EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine on Aβ42 induced cognitive deficiency in a rat model of Alzheimer's disease

Food & Function
Hongxia CheYuming Wang

Abstract

Ethanolamine plasmalogen (pPE), a major phospholipid in neuronal membranes, is specifically reduced in postmortem brains from patients with Alzheimer's disease (AD). The purpose of the present study was to compare the effects of EPA-enriched ethanolamine plasmalogen (EPA-pPE) and EPA-enriched phosphatidylethanolamine (EPA-PE) on cognitive deficiency and illustrate the possible underlying mechanisms. SD rats were divided into four groups including the sham group injected with 0.9% saline and three amyloid-β (Aβ) infusion groups, Aβ42 group, EPA-pPE group and EPA-PE group. EPA-pPE and EPA-PE were administered by gavage (150 mg kg-1 day-1), respectively, once a day for 26 days. Administration of EPA-pPE exerted better effects than EPA-PE in improving Aβ-induced cognitive deficiency in a rat model of Alzheimer's disease. Further mechanical research indicated that EPA-pPE was superior to EPA-PE in regulating oxidative stress via increasing SOD activity and decreasing MDA level, as well as reducing GSK-3β and tau phosphorylation. Moreover, EPA-PE was more effective than EPA-pPE at inhibiting the protein expressions of Bax and caspase 9. The results of neuro-inflammation and inflammasome activation showed that EPA-pPE exerted more sig...Continue Reading

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Citations

Oct 24, 2019·Journal of Alzheimer's Disease : JAD·Matthew Wai Kin WongAnne Poljak
Aug 28, 2020·Food & Function·Takumi TakahashiKiyotaka Nakagawa
Aug 24, 2019·Progress in Lipid Research·Tian-Tian ZhangChang-Hu Xue
Feb 2, 2021·Journal of Alzheimer's Disease : JAD·Daniel A LlanoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 16, 2020·Comprehensive Reviews in Food Science and Food Safety·Mirja Kaizer AhmmedAlaa El-Din Bekhit
Feb 28, 2021·Scientific Reports·Hiroya KadokawaShinichi Kitamura
Aug 31, 2020·Neurobiology of Disease·Fabian DorningerJohannes Berger
May 29, 2021·Scientific Reports·Letícia Leandro BatistaCarlos Ueira-Vieira
Jul 5, 2021·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jie WangHaixing Wang
May 28, 2019·Journal of Agricultural and Food Chemistry·Yue WuShu-Ping Hui
Feb 10, 2021·Current Molecular Pharmacology·Varsha KomallaMehra Haghi

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Methods Mentioned

BETA
column chromatography
protein assay
MDA

Software Mentioned

Prism
SPSS
- Pad
UVP LabWork
Graph

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