PMID: 18198485Jan 17, 2008Paper

A comparative study of histamine activities on differentiation of osteoblasts and osteoclasts

The Journal of Toxicological Sciences
Yoshiko IkawaKoichi Ueno

Abstract

The effects of histamine and its receptor antagonists on mouse bone marrow cells (MBMC) and MC3T3-E1 cells were studied to elucidate the precise molecular mechanisms underlying histamine activities in the respective cell types. The studied parameters were osteoclast differentiation and expressions of receptor activator of nuclear factor kappaB ligand (RANKL), histamine receptors (HR), and osteoblast differentiation markers. The osteoclastogenesis was assessed by TRAP-dye method. Expressions of RANKL, HR and the osteoblast differentiation markers were evaluated by RT-PCR analysis. In MBMC, 1 microM histamine doubled the number of osteoclast-like cells in a dose-dependent manner. Expressions of RANKL peaked at histamine concentrations of 1 microM and 0.1 microM in MBMC and MC3T3-E1, respectively. H(1)R antagonist, but not H(2)R antagonist, inhibited RANKL expressions induced by histamine in MC3T3-E1. Histamine induced expressions of cell differentiation markers in MC3T3-E1, but not in MBMC, under the conditions that RANKL expressions were induced by histamine in both types of cells. These results indicate the following: (1) Histamine induction of osteoclastogenesis is mediated by RANKL expressed via H(1)R, but not via H(2)R in mo...Continue Reading

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Citations

Nov 29, 2013·Journal of Periodontology·Renata LonghiniPaulo Sérgio Cerri
Jun 7, 2014·Pharmacological Reports : PR·Joanna FolwarcznaAnna Brzęczek
Feb 9, 2016·Scandinavian Journal of Gastroenterology·Kristin Matre AasarødReidar Fossmark
Apr 5, 2011·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Alja MehMartina Drevenšek
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Dec 12, 2020·Biomedicines·Gregor SperlChristian Kirschneck

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