A comparative study of Kimura's disease and IgG4-related disease: similarities, differences and overlapping features.

Histopathology
Xingen WangWeihua Yin

Abstract

To compare the fibroinflammatory diseases Kimura's disease (KD) and immunoglobulin (Ig)G4-related disease (IgG4RD) and to explore their possible relationship. Forty-six cases of KD and 29 IgG4RD from our institution diagnosed from 2011 to 2020 were studied. They were compared with each other on clinical, pathological and immunohistological features. There were similar clinical features, except that IgG4RD affected an older patient population, with more frequent salivary gland involvement and KD affected head and neck lymph nodes, and showed blood eosinophilia more frequently than IgG4RD. IgG4RD exhibited frequent storiform fibrosis and obliterative phlebitis, while KD showed more frequent tissue eosinophilia, eosinophilic abscess, germinal centre eosinophilic deposit and vascularisation. Twenty to 30% of KD had more than 50 IgG4+ plasma cells (PC) per high-power field (HPF) and IgG4/IgG+ PC ratio exceeding 40%. These parameters, however, occurred in 100% of IgG4RD. Significantly more KD had >10 IgE+ PC/HPF and lymphoid germinal centre IgE reticular staining compared to IgG4RD. All these histological and immunohistological features are overlapping in the two diseases, although they differed with statistical significance. Our stu...Continue Reading

References

Mar 1, 1989·The American Journal of Surgical Pathology·P K HuiE Gwi
Nov 1, 1996·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T J LiM Kitano
Jun 12, 1998·International Archives of Allergy and Immunology·D VercelliA Agresti
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Francois HuauxSem H Phan
Apr 17, 2004·The American Journal of Surgical Pathology·Hong ChenSusan L Abbondanzo
Oct 8, 2005·The Journal of Allergy and Clinical Immunology·Ignatius GomesSteven J Ackerman
Dec 19, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jean-Paul MeningaudJacques-Charles Bertrand
Apr 12, 2007·Archives of Pathology & Laboratory Medicine·Mohammad Abuel-Haija, Matthew T Hurford
Sep 14, 2007·Annals of Medicine·Lars K Poulsen, Lone Hummelshoj
Mar 29, 2008·Annual Review of Immunology·Janet StavnezerCarol E Schrader
Sep 24, 2008·Internal Medicine Journal·Q-F SunD-J Jin
Mar 10, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yasuharu SatoTadashi Yoshino
Aug 25, 2010·Advances in Anatomic Pathology·Wah Cheuk, John K C Chan
Feb 10, 2012·The New England Journal of Medicine·John H StoneVikram Deshpande
May 19, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Vikram DeshpandeJohn H Stone
Oct 12, 2013·Annual Review of Pathology·Vinay S MahajanJohn H Stone
Dec 20, 2013·Clinical Rheumatology·Lei LiuZhen Zhang
Mar 8, 2014·Digestive Diseases·Seema S Aceves
Oct 10, 2015·Dermatology : International Journal for Clinical and Investigative Dermatology·Diane KottlerMaxime Battistella
Sep 20, 2017·The Journal of Dermatology·Aoi OkuboTakuro Kanekura
Oct 27, 2017·Archives of Pathology & Laboratory Medicine·Steven C Weindorf, John Karl Frederiksen
Dec 5, 2019·Annals of the Rheumatic Diseases·Zachary S WallaceUNKNOWN Members of the ACR/EULAR IgG4-RD Classification Criteria Working Group
Sep 18, 2020·Nature Reviews. Rheumatology·Cory A Perugino, John H Stone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.