A comparative study of mitomycin C and 5-Fluorouracil trabeculectomy in west Africa.

Middle East African Journal of Ophthalmology
N Anand, V K Dawda

Abstract

To report the comparative efficacy and safety of intraoperative 5-fluorouracil (5-FU) or mitomycin C (MMC) in primary trabeculectomy in Nigeria. Retrospective chart review of patients undergoing primary antimetabolite trabeculectomy in Lagos, Nigeria between 1996 and 2003. We included 129 patients (132 eyes) of the 210 patients with greater than one year postoperative follow-up. Success rates between groups were compared by Kaplan-Meier survival analysis. IOP changes between groups were compared with ANOVA test. Non-parametric comparisons were performed with the Chi-square test with Yates correction or Fisher exact test. A P value less than 0.05 was considered statistically significant. Seventy-three eyes underwent 5-FU (5-FU group) and 59 eyes underwent MMC augmentation (MMC group) during primary trabeculectomy. The 5-FU group had longer mean follow-up of 53 ± 26 months than the MMC group (38 ± 18 months, P<0.001). The preoperative intraocular pressure was 25.4 ± 6.2 in the MMC group and 25.8 ± 6.0 mm Hg in the 5FU group (P=0.8). Postoperative IOPs were significantly lower (P<0.05) in the MMC group at all follow up visits except between 30-35 months (P=0.07). The probability of maintaining an IOP less than 19 mmHg and 15 mmHg ...Continue Reading

Citations

Jun 7, 2013·Middle East African Journal of Ophthalmology·Girum W Gessesse, Karim F Damji
Dec 7, 2013·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·A KoutsonasN Plange
Apr 28, 2018·European Journal of Ophthalmology·Bipul Kumer De SarkerMallika Mahatma
Aug 17, 2021·Journal of Current Glaucoma Practice·Egbula N EniJohn C Buchan
May 29, 2021·Journal of Glaucoma·Haaris A ShiwaniKarl J Mercieca

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