A comparative study of multiple clinical enterovirus 71 isolates and evaluation of cross protection of inactivated vaccine strain FY-23 K-B in vitro

Virology Journal
Ting YangQihan Li

Abstract

Enterovirus 71 (EV71) is one of the causative agents of hand, foot and mouth disease, which mostly affects infants and children and leads to severe neurological diseases. Vaccination offers the best option for disease control. We have screened the virus strain FY-23 K-B, which is used as an inactivated vaccine strain. An important issue in the development of vaccines is whether they provide cross protection against all other strains. We collected and identified 19 clinical EV71 isolates from mainland China, which all belong to the C4 genotype. We established growth curves of the strains in Vero cells, performed genetic analysis, and evaluated the cross protection efficacy through neutralizing assays using antisera from a rabbit, monkey and adult human immunized with the FY-23 K-B vaccine strain. The antisera showed broad cross protection among the C4 subgroup strains and homotype strain. Neutralizing indexes (NIs) among the isolates and homotype strain of antisera varied between 56.2-1995.3 for rabbit, 17.8-42,169.7 for monkey and 31.6-17,782.8 for human, whereas NIs against Coxsackievirus A16 or other enteroviruses were below 10. These results suggested that FY-23 K-B used as an antigen could elicit broad spectrum neutralizing...Continue Reading

References

Jan 14, 2004·The Journal of General Virology·Yi-Chun ChenHuan-Yao Lei
Jul 29, 2006·The Pediatric Infectious Disease Journal·Mitsuaki HosoyaHitoshi Suzuki
Feb 6, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mong How OoiTom Solomon
Jan 26, 2008·Emerging Infectious Diseases·Phan Van TuPeter Charles McMinn
Mar 10, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Yong ZhangWen-Bo Xu
Jan 30, 2010·Expert Review of Vaccines·Min-Shi Lee, Luan-Ying Chang
Oct 19, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yan WuVincent T K Chow
Oct 22, 2010·The Lancet Infectious Diseases·Tom SolomonMong How Ooi
Oct 23, 2010·Lancet Neurology·Mong How OoiTom Solomon
Feb 28, 2014·The New England Journal of Medicine·Fengcai ZhuNan Wang
Feb 28, 2014·The New England Journal of Medicine·Rongcheng LiQihan Li
Jan 7, 2016·Expert Review of Vaccines·Qun-ying MaoZhenglun Liang

❮ Previous
Next ❯

Citations

Jan 8, 2020·Communications Biology·Helen M E DuyvesteynDavid I Stuart
May 11, 2018·Emerging Microbes & Infections·Sabine M G van der SandenKatja C Wolthers
Jan 12, 2020·Communications Biology·Helen M E DuyvesteynDavid I Stuart

❮ Previous
Next ❯

Datasets Mentioned

BETA
AB059813

Software Mentioned

MEGA
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.