A comparative study of NADPH-diaphorase in the sympathetic preganglionic neurons of the upper thoracic cord between spontaneously hypertensive rats and Wistar-Kyoto rats

Brain Research
F R TangE A Ling

Abstract

With retrograde tracing using fluorogold injection into the superior cervical ganglion and nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) histochemistry, the present comparative study revealed that the retrogradely labelled neurons in n. intermediolateralis pars funicularis (ILf) and n. intermediolateralis pars principalis (ILp) of the autonomic region in the upper thoracic cord exhibited a much stronger reactivity for NADPH-diaphorase in Wistar-Kyoto (WKY) rats than those in spontaneously hypertensive rats (SHR). It was found that in ILf in WKY rats, 77.62% of the fluorogold-labelled neurons were NADPH-d positive, while in SHR, only 56.43% of the labelled neurons were NADPH-d positive. The frequency distribution of NADPH-d positive retrogradely labelled neurons was significantly reduced in ILf of the spinal cord of SHR (U-test: P < 0.01). In ILp in WKY rats, 65.25% of fluorogold-labelled neurons were NADPH-d positive in WKY rats, while in SHR, only 56.28% of the labelled neurons were NADPH-d positive. Although the difference (P > 0.05) in the frequency of NADPH-d positive neurons in ILp between the two strains of rats was not significant, the reductions in SHR seemed considerable. Examination of the pregangli...Continue Reading

References

Dec 7, 1992·Neuroscience Letters·N J DunL F Tseng
Jan 1, 1992·Neuroscience·S R Vincent, H Kimura
Jul 8, 1992·The Journal of Comparative Neurology·J G ValtschanoffA Rustioni
Apr 15, 1991·The Journal of Comparative Neurology·Y AimiH Kimura
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Jan 1, 1994·Annual Review of Neuroscience·E M Schuman, D V Madison
Mar 1, 1993·Hypertension·J DananbergR J Grekin

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