A comparative study of Ocusert Pilo 40, intensive pilocarpine and low-dose pilocarpine in the initial treatment of primary acute angle-closure glaucoma

Current Medical Research and Opinion
R S Edwards

Abstract

Acetazolamide and pilocarpine have a central role in the initial management of primary acute angle closure glaucoma (PACG), but there is no consensus concerning their mode of delivery, as borne out by a recent survey of senior UK ophthalmologists reported below. Ocusert Pilo 40 was developed to remain in situ releasing pilocarpine for up to one week. In view of its potential advantages, a trial of Ocusert Pilo 40's efficacy in PACG was conducted. In two separate controlled studies, eyes diagnosed with PACG were randomised to receive Ocusert Pilo 40, and either an intensive pilocarpine regimen or a low-dose pilocarpine treatment. All patients also received Diamox 500 mg i.v. Two hours after starting topical treatment, the study was terminated and ocular and systemic response to treatment and the eventual outcome were assessed. In both studies, intravenous Diamox caused a fall of intraocular pressure (IOP) within 30 min. Over the treatment period, a comparable reduction in IOP was seen in the Ocusert-treated, the intensive-pilocarpine-treated, and the low-dose-pilocarpine-treated groups. No damage to the corneas were observed.

References

Jan 15, 1990·Annals of Internal Medicine·D E Everitt, J Avorn
Sep 1, 1990·Archives of Ophthalmology·P L Krawitz, S M Podos
Mar 1, 1987·Archives of Internal Medicine·L LittmannT Fenyvesi
Jan 1, 1965·American Journal of Ophthalmology·E EPSTEIN, I KAUFMAN

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Citations

Oct 3, 2003·Ophthalmology·Seang-Mei SawDavid S Friedman
Aug 9, 2003·Expert Opinion on Drug Safety·Joel S Schuman
Dec 25, 2010·Veterinary Ophthalmology·Alan L Weiner, Brian C Gilger
Apr 20, 2004·The Journal of Emergency Medicine·Robert G HendricksonMichael I Greenberg
Sep 24, 2021·Deutsches Ärzteblatt International·Simone NüssleJan Lübke

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