A comparative study of PD-L1 immunohistochemical assays with four reliable antibodies in thymic carcinoma

Oncotarget
Tadashi SakaneHiroshi Inagaki

Abstract

Currently, four immunohistochemical assays are registered with the US Food and Drug Administration to detect the expression of PD-L1. We investigated the PD-L1 expression in thymic carcinomas using these four diagnostic assays. The cases of 53 patients were reviewed and their specimens were subjected to four PD-L1 assays with different antibodies (SP142, SP263, 22C3, and 28-8). The PD-L1 expression in tumor cells (TCs) and immune cells (ICs) was evaluated. In TCs, the four assays showed similar scores in each case. Histopathologically, high TC scores were observed in squamous cell carcinomas (SqCCs). Meanwhile, there were no significant relationships among the IC scores in the four assays. In SqCCs, the high expression of PD-L1 (defined as ≥50% TC score) in TCs tended to be associated with early stage cancer. The patients with high expression levels of PD-L1 tended to show longer overall survival in the 22C3 assays (p=0.0200). In thymic carcinomas, the staining pattern showed high concordance among the four assays when TCs - rather than ICs - were stained. High PD-L1 positivity in TCs, especially in SqCCs, indicated that PD-1/PD-L1 targeted therapy may be a promising therapeutic approach.

References

Aug 1, 1994·The Annals of Thoracic Surgery·T P TsaiS S Khan
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisAndrew G Nicholson
Oct 1, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G H WilliamsC Barker

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Citations

Aug 7, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emina TorlakovicMing-Sound Tsao
Jan 11, 2019·Breast Cancer Research and Treatment·Elisabeth Specht StovgaardDorte Nielsen
Oct 31, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Arutselvan NatarajanSanjiv S Gambhir
Jan 1, 2021·Journal of Cancer Research and Therapeutics·Hayriye SahinliNuriye Y Özdemir
Jan 4, 2021·Virchows Archiv : an International Journal of Pathology·Anja C Roden, Malgorzata Szolkowska
Oct 1, 2019·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Akihiro YoshimuraKoichi Takayama
Mar 18, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jordi RemonGiorgio V Scagliotti
May 14, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Shunta IshiharaMasayoshi Inoue
Apr 27, 2021·Pathology International·Tadashi SakaneHiroshi Inagaki
Oct 8, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Jordi RemonBenjamin Besse
Oct 26, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Alexander MarxPhilipp Ströbel

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Methods Mentioned

BETA
surgical resection
biopsy
biopsies

Software Mentioned

JMP

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