A comparative study of pentraxin-like proteins in different fish species

Developmental and Comparative Immunology
V Lund, J A Olafsen

Abstract

Pentraxins are a family of pentameric serum proteins that have been conserved in evolution and share sequence homology, similar subunit assembly and the capacity for calcium-dependent ligand binding. The classical pentraxins are human C-reactive protein (CRP) and serum amyloid P component (SAP). The sequence homology and gene organization indicate that they arose from a gene duplication of an ancestral pentraxin gene. They are usually isolated based on their affinity for phosphorylcholine and agarose, respectively. We have used this method for isolation of pentraxin-like proteins from normal serum of Atlantic salmon (Salmo salar), common wolffish (Anarhichas lupus), cod (Gadus morhua) and halibut (Hippoglossus hippoglossus). Although pentraxin structures have not been verified, the isolated proteins all appear to be pentraxin-like based on their binding specificity, molecular weight of subunits, cross-reactivity with antibodies to human pentraxins and N-terminal amino acid sequences. However, with the described method only one pentraxin-like protein was detected in each of the fish species.

References

Jul 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A J SzalaiL W Clem
May 1, 1990·Journal of Molecular Evolution·M J Benton
Jan 1, 1989·Developmental and Comparative Immunology·H KodamaH Izawa
Apr 1, 1984·The Journal of Experimental Medicine·C R HindM B Pepys
Jan 1, 1982·Journal of Immunological Methods·F C De Beer, M B Pepys
Jun 1, 1995·The Journal of Veterinary Medical Science·M MurataM Onuma
Sep 22, 1993·Proceedings. Biological Sciences·L T SeeryA S Whitehead
Feb 1, 1995·Current Opinion in Immunology·H GewurzT F Lint
Aug 1, 1994·The Journal of Veterinary Medical Science·M MurataH Kodama
Feb 1, 1994·Biochemical Society Transactions·G A Tennent, M B Pepys
Jul 1, 1995·Developmental and Comparative Immunology·L E JensenJ C Jensenius
Sep 12, 1998·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·V Lund, J A Olafsen
Sep 30, 1930·The Journal of Experimental Medicine·W S Tillett, T Francis

❮ Previous
Next ❯

Citations

Oct 17, 2001·Developmental and Comparative Immunology·C J Bayne, L Gerwick
Oct 17, 2001·Developmental and Comparative Immunology·A E Ellis
Sep 13, 2003·Developmental and Comparative Immunology·Jamie R CartwrightTrevor J Greenhough
Dec 17, 2011·Fish & Shellfish Immunology·Sigridur S AudunsdottirBirkir Th Bragason
Dec 17, 2008·Fish & Shellfish Immunology·Berglind GisladottirBergljot Magnadottir
Apr 29, 2008·Developmental and Comparative Immunology·Franz VillarroelMargarita I Concha
Jun 14, 2005·Fish & Shellfish Immunology·Bergljót Magnadóttir
Jul 7, 2009·Developmental and Comparative Immunology·Marit SeppolaHelge Tveiten
Sep 8, 2005·Veterinary Immunology and Immunopathology·Spencer Russell, John S Lumsden
Oct 5, 2018·BMC Genomics·Dwight R CauseyDaniel J Macqueen
May 23, 2019·Frontiers in Immunology·Asmita Pathak, Alok Agrawal
Nov 6, 2007·Fish & Shellfish Immunology·Shona K Whyte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.