PMID: 6412664Jul 1, 1983Paper

A comparative study of polychlorinated dibenzofurans, polychlorinated biphenyls and 2,3,7,8-tetrachlorodibenzo-p-dioxin on aryl hydrocarbon hydroxylase inducing potency in rats

Archives of Toxicology
J NagayamaM Kuratsune

Abstract

The aryl hydrocarbon hydroxylase (AHH) inducing potency of toxic chlorinated aromatic hydrocarbons such as polychlorinated dibenzofurans (PCDFs), polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was studied in the young male Wistar rats. Alternatively, a technical PCDF mixture, 15 individual PCDF isomers or TCDD were administered i.p. in doses of 5 micrograms/kg; a PCB mixture was given in a dose of 50 mg/kg. The order of AHH inducing ability was TCDD greater than PCDFs much greater than PCBs in kidney, lung, and liver. In the prostate, thymus, and spleen, only TCDD enhanced the AHH activity. The AHH inducibility in the lung and liver, induced by 15 pure PCDF isomers with varying chlorine substitutions was also examined. Only 2,3,7,8-tetrachlorodibenzofuran (2,3,7,8-tetra-CDF) and 2,3,4,7,8-pentachlorodibenzofurans (2,3,4,7,8-penta-CDF) significantly induced the hepatic AHH activity (4- and 2-fold, respectively), while eight PCDF isomers, including these two, significantly enhanced the pulmonary AHH activity (6- to 30-fold). Taking into account both the potent AHH inducibility and the high bioaccumulation of these compounds, 2,3,7,8-tetra- and 2,3,4,7,8-penta-CDF should be given due attention with...Continue Reading

References

May 31, 1979·Annals of the New York Academy of Sciences·H YoshimuraM Miki
Jun 1, 1977·Food and Cosmetics Toxicology·J NagayamaM Kuratsune
Jan 1, 1976·Bulletin of Environmental Contamination and Toxicology·J NagayamaY Masuda
Aug 1, 1980·Food and Cosmetics Toxicology·H KurokiH Yoshimura

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Citations

Jul 1, 1988·Bulletin of Environmental Contamination and Toxicology·P G OlafssonW Stone
Aug 1, 1989·Bulletin of Environmental Contamination and Toxicology·C KiyoharaT Hirohata
May 1, 1990·Journal of Toxicology and Environmental Health·G D BellwardL E Hart
Feb 1, 1985·Environmental Health Perspectives·Y MasudaJ Nagayama

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