A comparative study of Ro 03-8799: racemic mixture and enantiomers

The British Journal of Radiology
H F NewmanC E Smithen

Abstract

The maximum single dose of the 2-nitroimidazole hypoxic cell radiosensitiser Ro 03-8799 is limited to 1 g/m2 by the occurrence of a well characterised acute syndrome of sweating, nausea and mental changes. In an attempt to increase the tolerable dose, the clinical toxicity of the racemic mixture was compared with that of the R- and S-enantiomers of Ro 03-8799. Twelve patients received escalating alternate doses of racemic mixture and R- or S-enantiomer, the dose levels being 0.25 g/m2, 0.5 g/m2, 0.75 g/m2 and 1.0 g/m2. Careful monitoring of the acute syndrome failed to demonstrate any consistent differences between racemic mixture and either enantiomer. This would suggest that the toxicity is not mediated via any specific central nervous system receptor. It is concluded that separation of Ro 03-8799 into its enantiomers will not enable a clinically useful increase in dosage.

References

Jul 1, 1984·Medicinal Research Reviews·M Simonyi
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·J T RobertsM I Walton
Sep 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M I SaundersM Tothill

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Citations

Nov 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H F NewmanN M Bleehen
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·P WorkmanC E Smithen

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